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TranscriptomicsWhole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis
Purpose: to evaluate changes in the transcriptome of hippocampal cells during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures. Experimental Design: Gene expression profiling was analyzed in hippocampi of rats subjected ...
ORGANISM(S): Rattus norvegicus 
2010-02-09 | E-GEOD-14763 | biostudies-arrayexpress
ProteomicsProteomic profile of mouse hippocampus following kainate-induced epileptogenesis C4PR_LIV
Anti-epileptogenic agents that prevent the development of epilepsy following a brain insult remain the holy grail of epilepsy therapeutics. In order to identify such drugs, it is necessary to first understand the cellular and molecular events that underlie the epileptogenic process, from initial ins...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-23 | PXD010986 | Pride
Lc-msms Kainic acid Mouse Hippocampus Epileptogenesis 
GenomicsTimecourse of epileptogenesis in an TSC1 inducible mouse model
Timecourse of epileptogenesis in an TSC1 inducible mouse model
PRJNA689828 | ENA
GenomicsThe role of Methyl-CpG binding domain 3 (Mbd3) in epileptogenesis
The role of Methyl-CpG binding domain 3 (Mbd3) in epileptogenesis
PRJNA943198 | ENA
UnknownThe role of Methyl-CpG binding domain 3 (Mbd3) protein in epileptogenesis.
Not available
S-EPMC12507310 | biostudies-literature
TranscriptomicsRat MeDIP Array, naïve, epileptic, and adenosine treated
Epilepsy causes altered gene expression; transient adenosine treatment inhibits progression of epileptogenesis Hippocampus of epileptic rat is hypermethylated compared to naïve; adenosine treatment causes hypomethylation Metylation state in epileptic rats (9 weeks post kainic acid induced status epi...
ORGANISM(S): Rattus rattus 
2013-09-05 | E-GEOD-45932 | biostudies-arrayexpress
TranscriptomicsAlbumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.
Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuro...
ORGANISM(S): Rattus norvegicus 
2009-07-15 | E-GEOD-12304 | biostudies-arrayexpress
GenomicsNeuronal and glial DNA methylation and gene expression changes in early epileptogenesis
Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis
PRJNA574618 | ENA
TranscriptomicsTimecourse of epileptogenesis in an TSC1 inducible mouse model
To determine how the loss of TSC induces epileptogenesis, we made use of an inducible Tsc1 knock-out mouse model. Tsc1 was homozygously deleted in all CAMK2A positive neurons. Hippocampal tissue was collected at different time points after gene deletion and during epileptogenesis, of mice of both se...
ORGANISM(S): Mus musculus 
2021-11-11 | GSE164306 | GEO
UnknownGelatinase Biosensor Reports Cellular Remodeling During Epileptogenesis.
Not available
S-EPMC7186352 | biostudies-literature
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