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ProteomicsMouse 129SV submandibular salivary gland. -Male vs Female- and -Wildtype vs ERdj5 knockout-
In this study we have explored the effects of ERdj5 chaperone protein deletion in the proteome of 129SV mouse submandibular salivary glands. This knockout mouse model recapitulates many aspects of Sjögren’s Syndrome, including salivary gland inflammatory infiltrations, anti-nuclear autoantibodies an...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-21 | PXD026424 | Pride
Sjögren’s syndrome Mouse Salivary gland Sexual dimorphism Autoimmunity Erdj5 
GenomicsERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
PRJNA929541 | ENA
TranscriptomicsERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic reticulum-resident protein disulfide reductase that mediates the cleavage and degradation of misfolded proteins. Although ERdj5 expression is significantly higher ...
ORGANISM(S): Mus musculus 
2023-06-14 | GSE224087 | GEO
UnknownThe ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation.
Not available
S-EPMC3596249 | biostudies-literature
UnknownERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions.
Not available
S-EPMC9981579 | biostudies-literature
UnknownRedox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.
Not available
S-EPMC5068290 | biostudies-literature
UnknownCa2+ imbalance caused by ERdj5 deletion affects mitochondrial fragmentation.
Not available
S-EPMC8563984 | biostudies-literature
UnknownThe co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.
Not available
S-EPMC4240209 | biostudies-literature
UnknownMechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP.
Not available
S-EPMC10591012 | biostudies-literature
UnknownERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.
Not available
S-EPMC2397301 | biostudies-literature
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