Sort   by:  
 Page size 
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsBiochemical partitioning of RNA collectives reveals ProQ as a global RNA chaperone in bacteria
The vast number of noncoding RNAs in bacteria suggests that major post-transcriptional circuits beyond those controlled by the global RNA-binding proteins Hfq and CsrA may exist. To identify additional globally acting RNPs we have developed a method (gradient profiling by sequencing; Grad-seq) to pa...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2017-07-21 | PXD003360 | Pride
Salmonella enterica Ncrna 
ProteomicsTowards a quantitative assessment of the integral magnetosome membrane sub-proteome
Magnetosomes are membranous organelles than contain crystals of magnetic minerals and enable magnetotactic bacteria to orientate in magnetic fields. The enveloping magnetosome membrane was found to contain a subset of specific proteins that are encoded within a genomic island. However, along with pr...
ORGANISM(S): Magnetospirillum gryphiswaldense 
2017-10-24 | PXD006166 | Pride
Organelle Membrane proteome Magnetosome 
ProteomicsA novel mobile genomic island: introducing ‘cephalosporinase morons’ in Enterobacteriaceae
The exchange of mobile genomic islands (MGIs) between microorganisms is often mediated by phages. As a consequence, not only phage genes are transferred, but also genes that have no particular function in the phage's lysogenic cycle. If they provide benefits to the phage's host, such genes are refer...
ORGANISM(S): Enterobacter cloacae 
2018-08-21 | PXD007113 | Pride
"cephalosporin resistance " Enterobacteriaceae "mobile genomic islands " 
ProteomicsProteome Analysis of Actinoplanes sp. SE50/110
The acarviose metabolite acarbose is an a glucosidase inhibitor produced by Actinoplanes sp. SE50/110. It is medically important because it is used in the treatment of type 2 diabetes. In this work a comprehensive proteome analysis of Actinoplanes sp. SE50/110 was carried out. The associated txt and...
ORGANISM(S): Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) 
2015-10-21 | PXD001497 | Pride
Actinoplanes sp. se50/110 
ProteomicsIdentification of new protein-coding genes with a potential role in the virulence of the plant pathogen Xanthomonas campestris pv. vesicatoria
Bacteria of the genus Xanthomonas are economically important plant pathogens. Pathogenicity of Xanthomonas spp. depends on the type III-secretion system and additional virulence determinants. The number of sequenced Xanthomonas genomes increases rapidly, however, accurate annotation of these genomes...
ORGANISM(S): Xanthomonas campestris pv. vesicatoria str. 85-10 
2017-08-17 | PXD007140 | Pride
Ortho proteogenimic Genome re-annotation Proteogenome Translational start sites T3ss T4ss T6ss Xanthomonas 
ProteomicsNovel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids
The small GTPases H, K, and NRAS are molecular switches that are indispensable for proper regulation of cellular proliferation and growth. Mutations in this family of proteins are associated with cancer and result in aberrant activation of signaling processes caused by a deregulated recruitment of d...
ORGANISM(S): Homo sapiens (Human) 
2020-03-05 | PXD016827 | Pride
Ip-ms Protein-engineering Ras-binding domain 
ProteomicsComparative proteomics of purified pathogen vacuoles correlates intracellular replication of Legionella pneumophila with the small GTPase Rap1
Legionella pneumophila is an opportunistic bacterial pathogen that causes a severe lung infection termed “Legionnaires’ disease”. The pathogen replicates in environmental protozoa as well as in macrophages within a unique membrane-bound compartment, the Legionella-containing-vacuole (LCV). Formation...
ORGANISM(S): Legionella 
2017-02-10 | PXD004797 | Pride
Host-pathogen interactions Macrophage Proteomics Phosphoinositide lipid Bacterial effector protein Legionella Type iv secretion Pathogen vacuole Small gtpase Amoeba Dictyostelium discoideum 
ProteomicsEvolution of an outbreak of meningococcal disease among men who have sex with men
Neisseria meningitidis (meningococcus) is usually transmitted via respiratory droplets, whereas its close relative, the gonococcus is sexually transmitted. Invasive meningococcal disease due to isolates of serogroup C increased in Europe and the United States among men who have sex with men (MSM). ...
ORGANISM(S): Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) 
2016-05-18 | PXD001498 | Pride
Evolution Ania Neisseria meningitidis 
UnknownIntersession Experience Questionnaire Short (IEQ-S): psychometric properties and longitudinal associations with symptoms of an 8-item short version of the Intersession Experience Questionnaire.
Not available
S-EPMC12685439 | biostudies-literature
Sort   by:  
 Page size