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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownEpigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.
Not available
S-EPMC3890604 | biostudies-literature
UnknownClassroom-based physical activity improves children's math achievement - A randomized controlled trial.
Not available
S-EPMC6296522 | biostudies-literature
TranscriptomicsGenome-wide copy number analysis of patient-derived gliobastoma cell cultures
Genome-wide copy number variation profiles were analyzed in the patient-derived gliobastoma cell culture samples. For this purpose, gDNA was analyzed using the CytoScan® assay in combination with a one-color based labeling and hybridization protocol. Signals on the CytoScan® HD microarrays were dete...
ORGANISM(S): Homo sapiens 
2019-02-28 | E-MTAB-7649 | biostudies-arrayexpress
ProteomicsS. aureus COL anaerobiosis absolute protein quantification
Absolute protein quantification was applied to follow the dynamics of the cytoplasmic proteome of Staphylococcus aureus in response to long-term oxygen starvation. For 1,168 proteins, the majority of all expressed proteins, molecule numbers per cell have been determined to monitor the cellular inves...
ORGANISM(S): Staphylococcus aureus (strain COL) 
2016-07-11 | PXD000330 | Pride
Absolute protein quantification Lc-mse Anaerbiosis Synapt Lc-imse Staphylococcus aureus 
TranscriptomicsComplete hematologic response of early-T-cell progenitor acute lymphoblastic leukemia to the gamma-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
Notch pathway antagonists such as gamma-secretase inhibitors (GSI) are being tested in diverse cancers, but exceptional responses have yet to be reported. We describe the case of a patient with relapsed/refractory early-T-cell progenitor acute lymphoblastic leukemia (ETP-ALL) who achieved a complete...
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-71414 | biostudies-arrayexpress
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
UnknownSeasonal influenza vaccines: Variability of immune responses to B lineage viruses.
Not available
S-EPMC11581161 | biostudies-literature
TranscriptomicsMapping and analysis of chromatin state dynamics in nine human cell types (gene expression)
Chromatin profiling has emerged as a powerful means for annotating genomic elements and detecting regulatory activity. Here we generate and analyze a compendium of epigenomic maps for nine chromatin marks across nine cell types, in order to systematically characterize cis-regulatory elements, their ...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-26312 | biostudies-arrayexpress
UnknownHealth Characteristics and Aspirin Use in Participants at the Baseline of the ASPirin in Reducing Events in the Elderly - eXTension (ASPREE-XT) Observational Study.
Not available
S-EPMC10330669 | biostudies-literature
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