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ProteomicsKLF1-activated macrophages proteomic analysis
In this project we did a proteomic analysis from iPSCs-derived macrophages with the activation of thranscription factor KLF1, upon tamoxifen induction. These macrophages are a model for the study of the erythroid island (EI) niche in adult hematopoietic tissues, such as bone marrow and spleen. We wa...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050357 | Pride
Macrophages Erythroid island niche Ipscs Proteomics Klf1 
TranscriptomicsCo-culture of human hematopoietic stem cells with osteoblasts affects mono/macrophage versus erythroid lineage choice.
Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs interact with a variety of stromal cells. Though several components of the stem cell niche have been identified, the regulatory mechanisms through w...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-38091 | biostudies-arrayexpress
UnknownGenetic programming of macrophages generates an in vitro model for the human erythroid island niche.
Not available
S-EPMC6382809 | biostudies-literature
UnknownExtrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.
Not available
S-EPMC4034424 | biostudies-literature
TranscriptomicsTranscriptome analysis of erythroblastic island macrophages
The erythroblastic island (EBI), composed of a central macrophage and surrounding erythroid cells, was the first hematopoietic niche discovered. The identity of EBI macrophages has thus far remained elusive. Gene expression profiles of BM F4/80+Epor-eGFP+ macrophages suggest a specialized function i...
ORGANISM(S): Mus musculus 
2019-05-31 | GSE127980 | GEO
UnknownModelling the erythroblastic island niche of dyserythropoietic anaemia type IV patients using induced pluripotent stem cells.
Not available
S-EPMC10126837 | biostudies-literature
GenomicsTranscriptome analysis of erythroblastic island macrophages
Transcriptome analysis of erythroblastic island macrophages
PRJNA525977 | ENA
UnknownProteomic analysis reveals a potential role for extracellular vesicles within the erythroblastic island niche.
Not available
S-EPMC11058792 | biostudies-literature
UnknownTranscriptional Control of Gene Expression and the Heterogeneous Cellular Identity of Erythroblastic Island Macrophages.
Not available
S-EPMC8646026 | biostudies-literature
UnknownSelenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis.
Not available
S-EPMC5992864 | biostudies-literature
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