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TranscriptomicsExosc8-Regulated Genes in Fetal Liver-Derived Erythroid Progenitor Cells
Exosc8 and Exosc9 are components of the exosome that establish a barricade to erythroid maturation. Here, we knocked down Exosc8 in fetal liver-derived erythroid progenitor cells to determine the cohort of Exosc8-regulated genes in erythroid cells. Freshly isolated fetal liver progenitor cells were ...
ORGANISM(S): Mus musculus 
2014-08-09 | E-GEOD-60136 | biostudies-arrayexpress
TranscriptomicsDownstream Targets of HOXB4 in the primitive hematopoietic progenitor EML Cell line
Enforced expression of the homeobox transcription factor HOXB4 has been shown to enhance hematopoietic stem cell (HSC) self-renewal and expansion ex vivo and in vivo. In order to investigate the largely unknown downstream targets of HOXB4 in hematopoietic progenitor cells, HOXB4 was constitutively ...
ORGANISM(S): Mus musculus 
2010-04-20 | E-GEOD-20604 | biostudies-arrayexpress
TranscriptomicsNKL homeobox genes NKX2-3 and NKX2-4 deregulate megakaryocytic-erythroid cell differentiation in AML
NKL homeobox genes encode transcription factors which impact normal development and hematopoietic malignancies if deregulated. Recently, we established a NKL-code which describes the physiological expression pattern of eleven NKL homeobox genes in the course of hematopoiesis, allowing evaluation of ...
ORGANISM(S): Homo sapiens 
2021-10-31 | E-MTAB-10941 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse erythroblasts during erythroid differentiation
The I/11 and R10 erythroid progenitor cell line was cultivated in serum free medium (StemPro34) supplemented with Epo (0,5U/ml), SCF (100ng/ml) and dexamethasone (10-6M). To identify genes specifically regulated by Epo/SCF-induced polysome recruitment, cells were factor deprived for 4h and subsequen...
ORGANISM(S): Mus musculus 
2008-07-11 | E-MEXP-1689 | biostudies-arrayexpress
TranscriptomicsDynamic transcriptomes during human erythroid differentiation and development
To explore the mechanisms controlling erythroid differentiation and development in human, we analyzed the genome-wide transcription dynamics that occurs during the differentiation of HESCs into the erythroid lineage and development of embryonic to adult erythropoiesis using high throughput sequencin...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-32991 | biostudies-arrayexpress
TranscriptomicsExpression data from Fog1+/+ and Fog1 ki/ki mouse megakaryocyte-erythroid progenitors (MEP).
The transcription co-factor FOG1 interacts with the chromatin remodeling complex NuRD to mediate gene activation and gene repression during hematopoiesis. We have generated mice with a targeted mutation in the endogenous Fog1 locus that results in an N-ternimal mutation in FOG1 that disrupts the int...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-19497 | biostudies-arrayexpress
UnknownEstablishment of an erythroid cell line from primary CD36+ erythroid progenitor cells.
Not available
S-EPMC6341492 | biostudies-literature
TranscriptomicsSCL and c-Kit controlled gene expression in erythroid progenitor cell line
SCL/TAL1, a tissue-specific transcription factor of the basic helix-loop-helix (bHLH) family, and c-Kit, a tyrosine kinase receptor, control hematopoietic stem cell survival and quiescence. Here we report that SCL and c-Kit signaling control a common gene expression signature, of which 19 genes are ...
ORGANISM(S): Homo sapiens 
2013-07-06 | E-GEOD-48557 | biostudies-arrayexpress
TranscriptomicsErythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin
Epigenetic memory in induced pluripotent stem cells (iPSCs), with regards to their somatic cell type of origin, might lead to variations in their differentiation capacities. In this context, iPSCs from human CD34+ hematopoietic stem cells (HSCs) might be more suitable for hematopoietic differentiati...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-55109 | biostudies-arrayexpress
ProteomicsDevelopment of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies
β-hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemia (BT), are the most common inherited monogenic blood disorders globally. Despite decades of research, there are only four FDA-approved medications available for the management of SCD with hydroxyurea (HU) being the most widel...
ORGANISM(S): Homo sapiens (Human) 
2024-02-07 | PXD044642 | Pride
Proteomics Mass spectrometer Sickle cell disease Erythroid progenitor line Crispr/cas9 10-plex tmt label Β-thalassemia 
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