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ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
2024-10-15 | PXD056836 |
GenomicsESCRT-mediated machinery directly drives cardiac T-tubule formation
ESCRT-mediated machinery directly drives cardiac T-tubule formation
PRJNA1153460 | ENA
GenomicsESCRT-mediated machinery directly drives cardiac T-tubule formation
ESCRT-mediated machinery directly drives cardiac T-tubule formation
PRJNA1154598 | ENA
ProteomicsLEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
Quantitative crosslinking analysis to probe in vitro conformational dynamics governing ESCRT-mediated nuclear envelope formation. CHMP7 was crosslinked with D12-BS3 while CHMP7 in the presence of LEM2 winged helix domain was crosslinked with H12-BS3. Samples were mixed after crosslinking and analy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-24 | MSV000084837 | MassIVE
ProteomicsThe Flemmingsome reveals an ESCRT-to-membrane coupling required for cytokinesis
Cytokinesis requires the constriction of ESCRT-III filaments on the midbody side, where abscission occurs. After ESCRT recruitment at the midbody, it is not known how the ESCRT-III machinery localizes to the abscission site. We obtained the proteome of intact, post-abscission midbodies (Flemmingsome...
ORGANISM(S): Homo sapiens (Human) 
2020-05-22 | PXD013219 | Pride
Human Escrt machinery Cytokinesis Midbody Qexactive Lc-ms/ms 
TranscriptomicsESCRT-mediated machinery directly drives cardiac T-tubule formation
Cardiac transverse tubules (T-tubules) are regular spaced plasma membrane invaginations that play an essential role in establishing excitation-contraction coupling of cardiomyocytes, yet the molecular machinery that controls T-tubule formation remains elusive. The endosomal sorting complex required ...
ORGANISM(S): Mus musculus 
2026-03-03 | GSE276054 | GEO
TranscriptomicsESCRT-mediated machinery directly drives cardiac T-tubule formation
Cardiac transverse tubules (T-tubules) are regular spaced plasma membrane invaginations that play an essential role in establishing excitation-contraction coupling of cardiomyocytes, yet the molecular machinery that controls T-tubule formation remains elusive. The endosomal sorting complex required ...
ORGANISM(S): Mus musculus 
2026-03-03 | GSE275879 | GEO
GenomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
PTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
PRJNA1135166 | ENA
UnknownAsgard ESCRT-III and VPS4 reveal conserved chromatin binding properties of the ESCRT machinery.
Not available
S-EPMC9751279 | biostudies-literature
UnknownDistribution of ESCRT machinery at HIV assembly sites reveals virus scaffolding of ESCRT subunits.
Not available
S-EPMC4791044 | biostudies-literature
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