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MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Mixed-mode column chromatography)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2497 | MetaboLights
MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Data-independent acquisition)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2959 | MetaboLights
Proteomicsran asters proteomics - Proteomic profiling of microtubule self-organization in M-phase
The main proteomics events driving the self-organization of MTs in M-phase cytoplasms are determined by obtaining the full proteomes of the RanGTP induced MT structures at different time points in Xenopus egg extracts.
ORGANISM(S): Xenopus laevis (African clawed frog) 
2018-07-11 | PXD008306 | Pride
Ran asters proteomics 
ProteomicsCovalent histone modification by an electrophilic derivative of the anti-HIV drug nevirapine
Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor widely used in combined antiretroviral therapy and to prevent mother-to-child transmission of the human immunodefi-ciency virus type 1, is associated with several adverse side effects. Using 12-mesyloxy-nevirapine, a model electroph...
ORGANISM(S): Homo sapiens (Human) 
2021-03-08 | PXD023751 | Pride
Covalent histone modification  mass spectrometry  drug-induced adverse reactions  covalent protein adducts  nevirapine 
ProteomicsLOSS OF DKC1 IN CUTANEOUS SQUAMOUS CELL CARCINOMA RESULTS IN A METABOLIC REWIRING AND THE ACQUISITION OF METASTATIC TRAITS LOSS OF DKC1 RESULTS IN THE ACQUISITION OF A LIPIDIC METABOLISM AND METASTATIC TRAITS IN CUTANEOUS SQUAMOUS CELL CARCINOMA OTROS TITULOS
Metastaticsis disease remains, by far, the leading cause of all cancer-related deaths, despite being a process highly inefficient. The metastatic process is highly inefficient as the initial dissemination of cancer cells from many primary tumors involves intravasation to lymphatics nodes or blood ve...
ORGANISM(S): Homo sapiens (Human) 
2023-01-31 | PXD034155 | Pride
Metabolism Epigenetics Squamous cell carcinoma Snorna Dkc1 Metastasis Lc-msms 
ProteomicsThe loss of the RNA helicase Dhx15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice
DHX15 is an ATP-dependent RNA helicase involved in pre-mRNA splicing. We have recently reported that DHX15 is a downstream substrate for Akt1, which plays a significant role in vascular biology. Therefore, we aimed to explore the regulatory function of DHX15 over the vasculature, and the endothelial...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-04 | PXD018104 | Pride
Ltq-orbitrap fusion lumos 
GenomicsCustom 192-plex
VeraCode GoldenGate GT Assay technology
EGAD00010000853 | EGA
GenomicsSNP genotyping data in genes related to trace element homeostasis
In this study we provide data regarding sample charactheristics and genotypes in 150 human samples of European origin for SNPs located around genes related to metal homeostasis. SNPs were genotyped with the Illumina VeraCode technology (192-plex format). The genotyped SNPs were used to identify quan...
EGAS00001001292 | EGA
GenomicsUPF - Evolutionary Population Genetics lab Data Access Committee
Data Access Committee EGAC00001000244
EGAC00001000244 | EGA
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