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ProteomicsThe type III secretion system effector EspO of enterohemorrhagic Escherichia coli inhibits apoptosis through an interaction with HAX-1
Many enteric pathogens employ a type III secretion system (T3SS) to translocate effector proteins directly into the host cell cytoplasm, where they subvert signaling pathways of the intestinal epithelium. Here, we report that the anti-apoptotic regulator HS1-associated protein X1 (HAX-1) is an inter...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2021-10-15 | PXD023126 | Pride
Human Msms Espo E.coli 
UnknownThe type III secretion system effector EspO of enterohaemorrhagic Escherichia coli inhibits apoptosis through an interaction with HAX-1.
Not available
S-EPMC7613270 | biostudies-literature
UnknownThe Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses.
Not available
S-EPMC6221368 | biostudies-literature
ProteomicsDysregulated neutrophil response drives lethality during Citrobacter rodentium infection in interleukin-22 deficient mice
Citrobacter rodentium (CR) is a murine enteric pathogen widely used to model attaching and effacing bacterial disease caused by enteropathogenic and enterohaemorrhagic Escherichia coli. Infection induces colonic epithelial damage and inflammation that resolves in resistant mice but results in severe...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-08 | PXD074250 | Pride
Rodentium infection Mice Citrobacter Interleukin-22 deficient 
UnknownAn ensemble of bias-adjusted CMIP6 climate simulations based on a high-resolution North American reanalysis.
Not available
S-EPMC10784550 | biostudies-literature
UnknownDeletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia.
Not available
S-EPMC3172981 | biostudies-literature
UnknownNeonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium.
Not available
S-EPMC8586719 | biostudies-literature
UnknownIncreased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland.
Not available
S-EPMC3314680 | biostudies-literature
ProteomicsIntestinal crypt cells and the microbiome undergo abrupt reprogramming at the onset of colonic infection
We used the mouse pathogen Citrobacter rodentium to model gut infections. Following oral inoculation C. rodentium resides in the caecum for the first 3 days, before it infects the colon on the 4th day. Here we show that while the host is unresponsive to the infection on day 3, there is an abrupt rep...
ORGANISM(S): Citrobacter rodentium Mus musculus (Mouse) 
2019-03-05 | PXD012031 | Pride
Colon Infection Mouse Citrobacter Tmt 
ProteomicsC. rodentium remodels metabolism in IEC
The mechanisms by which the mouse pathogen Citrobacter rodentium triggers effacement of the brush border microvilli, colitis, hyperplasia and dysbiosis remain poorly understood. We investigated the impact of C. rodentium infection on the proteomic and metabolic landscapes of intestinal epithelial ce...
ORGANISM(S): Citrobacter rodentium Mus musculus (Mouse) 
2018-01-10 | PXD005004 | Pride
Colon Lc-msms Citrobacter rodentium Mouse Tmt Phosphorylation 
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