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GenomicsH4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription
Hormone-dependent gene expression requires dynamic and coordinated epigenetic changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon extensive chromatin remodeling and changes in histone modifications for the induction of hormone-responsive gene expression. Our previo...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-65886 | biostudies-arrayexpress
TranscriptomicsRERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer
Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG exp...
ORGANISM(S): Homo sapiens 
2005-07-23 | E-GEOD-2987 | biostudies-arrayexpress
UnknownNeurotrimin is an estrogen-regulated determinant of peripheral sympathetic innervation.
Not available
S-EPMC2577172 | biostudies-literature
TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
ProteomicsDynamics of protein expression reveals primary targets and secondary messengers of estrogen receptor signaling in MCF-7 breast cancer cells
Estrogen receptor-mediated proliferation of breast cancer cells is facilitated through expression of multiple primary target genes, products of which induce the secondary response to stimulation. To differentiate between the primary and secondary target genes of estrogen receptor signaling, we measu...
ORGANISM(S): Homo sapiens (Human) 
2016-04-14 | PXD002797 | Pride
Estradiol Srm Estrogen receptor Ere Silac Estrogen-regulated proteins Mcf-7 
TranscriptomicsTranscription profiling of human primary osteoblasts treated with estradiol or the pure antagonist ICI 182,780a potent inhibitor of estrogen receptor signaling
Transcriptional profiling of estrogen regulated genes in human primary osteoblasts. The cells were either treated with estradiol (1 nM) or the pure antagonist ICI 182,780 (Faslodex), which acts as a potent inhibitor of estrogen receptor signaling.
ORGANISM(S): Homo sapiens 
2007-08-01 | E-MEXP-1053 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary human breast tumors showing poor clinical prognosis
Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG exp...
ORGANISM(S): Homo sapiens 
2005-06-22 | E-SMDB-1443 | biostudies-arrayexpress
UnknownOrai3 is an estrogen receptor α-regulated Ca²⁺ channel that promotes tumorigenesis.
Not available
S-EPMC3528310 | biostudies-literature
ProteomicsGYLATL1 promotes endocrine therapy resistance in luminal A-like breast cancer and is regulated by estrogen-independent ERα signaling
Luminal A breast cancer is characterized by the expression and activity of estrogen receptor-α (ERα), a biomarker and therapeutic target. While endocrine therapies targeting ER signaling have shown efficacy, long-term success is limited by the development of resistance. Almost 40% of ER-positive bre...
ORGANISM(S): Homo sapiens (Human) 
2026-01-30 | PXD067936 | Pride
Breast cancer Prm Glyatl1 Endocrine therapy resistance Dia 
UnknownThe catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription.
Not available
S-EPMC1570434 | biostudies-literature
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