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MetabolomicsMetabolomic Analysis Reveals an Important Role of Sphingosine 1-phosphate in the Development of HFMD due to EV-A71 Infection

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovi...

2024-11-14 | MTBLS11656 | MetaboLights
ProteomicsEV71 proteomics - Analysis of EV71 infection progression using triple-SILAC-based proteomics approach
Enterovirus 71 (EV71), a member of Picornaviridae, causes severe neurological and systemic illness in children. To better understand the virus-host cell interactions, we performed a triple-SILAC-based quantitative proteomics study monitoring host cell proteome changes after EV71 infection. Based on ...
ORGANISM(S): Homo sapiens (Human) 
2015-08-31 | PXD002483 | Pride
Enterovirus 71  tripletof 5600  triple silac  proteomics 
ProteomicsGlobal quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection
Enterovirus 71 (EV71) is one of the leading causes of hand, foot and mouth disease with neurological complications in some cases. To study the pathogenesis of EV71 infection, large scale analyses of EV71 infected cells have been performed. However, most of these studies employed rhabdomyosarcoma (RD...
ORGANISM(S): Homo sapiens (Human) 
2015-09-15 | PXD002454 | Pride
Traf6 Silac Ev71 Quantitative proteomics Traf2 
TranscriptomicsExpression profile of EV71-infection-responsive miRNAs
We attempted to identify potential miRNAs that can regulate viral replication by screening host miRNAs in EV71-infected RD cells. To compare the differential expression of miRNAs in EV71-infected cells at different time points, miRNA expression profiles were analyzed using Agilent Human MicroRNA Arr...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-75455 | biostudies-arrayexpress
TranscriptomicsHomo sapiens PBMCs: pre-vaccination (stimulation vs. no stimulation with EV71 antigen) vs. post-vaccination (stimulation vs. no stimulation with EV71 antigen)
To characterize the primary and recall responses to EV71 vaccines, PBMC from 19 recipients before and after vaccination with EV71 vaccine are collected and their gene expression signatures after stimulation with EV71 antigen were compared. Four-condition experiment,pre-vaccination PBMCs (stimulation...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-72618 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of EV71 infected HT29 cells
HT29 cells was infected with EV71 at MOI 1 or nil respectively and harvested at 36hpi We use miRNA microarray to profile and identify miRNA which are up or down regulated due to EV71 infection 3 biological replicate (6 samples)
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-57372 | biostudies-arrayexpress
GenomicsLL-37 inhibits EV71 infection by upregulating STAC
LL-37 inhibits EV71 infection by upregulating STAC
PRJNA1370898 | ENA
TranscriptomicsComparison Analysis of microRNAs in Response to EV71 and CA16 Infection in Human Bronchial Epithelial Cells by High-Throughput Sequencing to Reveal Differential Infective Mechanisms
To compare MicroRNA expression in 16HBE infected with EV71 and CA16 we defined the following experimental groups: EV71-0h, EV71-6h, EV71-12h, CA16-0h, CA16-6h and CA16-12h
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-85829 | biostudies-arrayexpress
GenomicsMild, moderate and severe enterovirus 71 (EV71) isolates infection in human PBMCs
Mild, moderate and severe enterovirus 71 (EV71) isolates infection in human PBMCs
PRJNA560788 | ENA
GenomicsExpression profile of EV71-infection-responsive miRNAs
We attempted to identify potential miRNAs that can regulate viral replication by screening host miRNAs in EV71-infected RD cells. To compare the differential expression of miRNAs in EV71-infected cells at different time points, miRNA expression profiles were analyzed using Agilent Human MicroRNA Arr...
ORGANISM(S): Homo sapiens 
2016-01-01 | GSE75455 | GEO
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