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ProteomicsIn-depth proteome analysis of brain tissue from Ewsr1 gene knock-out mice
Ewing’s Sacroma (EWS) is a carcinogenic bone tumor which is predominantly occurred in young adults. EWS RNA binding protein 1 (Ewsr1) protein is well-known as a multifunctional protein and its epigenetic signatures contribute to the pathogenesis of various human disease such as neurodegenerative dis...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-16 | PXD026994 | Pride
Ewsr1 Mice Tandem mass tag 
ProteomicsSuper-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)
Desmoplastic small round cell tumor (DSRCT) is a highly aggressive cancer predominantly occurring in young male adolescents. It mainly arises at sites lined by mesothelium, such as the abdominal cavity, and is driven by the pathognomonic EWSR1::WT1 fusion oncoprotein. The dismal survival rates (5–20...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD053786 | Pride
Super-enhancer Dsrct Proteomics Scrna-seq Cacna2d2 Ewsr1::wt1 Ihc Biomarker 
ProteomicsSystematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although the paucity of additional mutations makes EwS a genuine model to study principles of cooperation between dominant fusion oncogenes an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-18 | PXD052856 | Pride
Cell culture Ewing sarcoma 
ProteomicsImmunoprecipitation followed by PRM to detect endogenous interaction between VGLL3 and EWSR1
For immunoprecipitation to detect the endogenous interaction between VGLL3 and EWSR1, cardiac myofibroblasts were fixed with 0.1% PFA and lysed in IP buffer [20 mM HEPES­NaOH (pH 7.5)/1 mM EGTA/1 mM MgCl2/150 mM NaCl /5% glycerol/1% NP­40] containing protease inhibitors (1:100) and phosphatase inhib...
ORGANISM(S): Mus Musculus (mouse) 
2022-12-24 | PXD039092 | JPOST Repository
TranscriptomicsGene expression profiling of human Ewing sarcoma cells after knockdown of EGR2 or EWSR1-FLI1.
To get insight in the functional role of EGR2 for Ewing sarcoma, we performed a transcriptional profiling of Ewing sarcoma cells after knockdown of EGR2 and compared the resulting transcriptional signature with that of EWSR1-FLI1-silenced Ewing sarcoma cells. In accordance with the strong EGR2-induc...
ORGANISM(S): Homo sapiens 
2015-07-26 | E-GEOD-62090 | biostudies-arrayexpress
GenomicsRNAseq comparing mouse Cre-loxP-induced EWSR1-ATF1 expression from Rosa26 versus Ewsr1-Atf1 translocation
RNAseq comparing mouse Cre-loxP-induced EWSR1-ATF1 expression from Rosa26 versus Ewsr1-Atf1 translocation
PRJNA666355 | ENA
GenomicsCharacterization of the specific EWSR1-FLI1 activity signature
Characterization of the specific EWSR1-FLI1 activity signature
PRJNA530244 | ENA
GenomicsThe effects of the loss of EWSR1 on alternative splicing
The effects of the loss of EWSR1 on alternative splicing
PRJNA1125342 | ENA
GenomicsEWSR1 is critical for post-meiotic transcription and spermiogenesis
EWSR1 is critical for post-meiotic transcription and spermiogenesis
PRJNA495175 | ENA
GenomicsEWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (CUT&RUN)
EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (CUT&RUN)
PRJNA1017516 | ENA
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