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MetabolomicsUntargeted metabolomics on plasma from children with asthma, comparing exacerbation-prone to non-exacerbation-prone
Not available
ORGANISM(S): Homo sapiens 
ST002251 | MetabolomicsWorkbench
MetabolomicsMulti-omics analysis of host airway responses in pediatric Mycoplasma pneumoniae pneumonia reveals potential mechanisms of disease exacerbation caused by co-infection

Respiratory viral co-infections in children with Mycoplasma pneumoniae pneumonia (MPP) are common and cause severe clinical manifestations. However, the exact pathogenic mechanisms of MPP co-infections are still unclear. In this study, we conducted a large-scale clinical analysis of 3,106 MPP pat...

2025-11-25 | MTBLS12635 | MetaboLights
TranscriptomicsGene Expression Patterns in Peripheral Blood Mononuclear Cells Associated with Asthma Exacerbation Attack
A large, prospective, non-interventional study was designed to study gene expression changes in peripheral blood mononuclear cells (PBMCs) associated with asthma exacerbations over the course of a year. PBMC samples were collected from subjects at the time of the study visits defined as 1) Quiet: du...
ORGANISM(S): Homo sapiens 
2011-07-13 | E-GEOD-19301 | biostudies-arrayexpress
ProteomicsThe rhinobiome of exacerbated preschool wheezers & asthmatics: insights from a German pediatric exacerbation network
Although the nose, as a gateway for organism-environment interactions, may have a key role in asthmatic exacerbation, the rhinobiome of exacerbated children with asthma was widely neglected to date. Deep nasopharyngeal swab specimens, nasal epithelial spheroid cultures (NAEsp), and blood samples of ...
ORGANISM(S): Moraxella catarrhalis 
2021-05-27 | PXD024694 | Pride
Nasal microbiome Metagenomics Moraxella catarrhalis Asthma Bioinformatics Proteomics Bacteria Exacerbation 
TranscriptomicsVirus-induced inflammatory gene networks underlying asthma exacerbations in vivo
Global patterns of gene expression was profiled in nasal lavage samples obtained from asthmatic children during an acute Picornavirus-induced exacerbation and 7-14 days later. Gene coexpression network analysis and prior knowledge was employed to reconstruct the wiring diagram of the underlying gene...
ORGANISM(S): Homo sapiens 
2011-12-11 | E-GEOD-30326 | biostudies-arrayexpress
MetabolomicsSerum metabolomics analysis of patients with chronic obstructive pulmonary disease and 'frequent exacerbator' phenotype

BACKGROUND: Chronic obstructive pulmonary disease (COPD) exacerbations significantly contribute to morbidity and mortality. The complex nature of COPD presents challenges in accurately predicting and understanding frequent exacerbations.

OBJECTIVE: This stu...

2024-02-23 | MTBLS9119 | MetaboLights
ProteomicsA Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis
A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis
ORGANISM(S): Staphylococcus sp. KDM4 
2020-04-22 | PXD017818 | Pride
Staphylococcus pro-apoptotic peptide 
GenomicsInnate immune responses are increased in children with acute asthma exacerbation
Innate immune responses are increased in children with acute asthma exacerbation
PRJNA1080008 | ENA
TranscriptomicsVastus lateralis muscle of patients with an acute COPD exacerbation
To further unravel the potential molecular mechanisms involved in the loss of muscle function during an acute exacerbation, a cross-sectional microarray study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable ...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-10828 | biostudies-arrayexpress
TranscriptomicsAsthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures.
Acute respiratory illness (ARI) is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular mechanisms driving ARI-induced asthma exacerbations, we undertook a transcriptional profiling ...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-46171 | biostudies-arrayexpress
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