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TranscriptomicsIdentification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons (array)
To identify the activity-induced gene expression programs in inhibitory and excitatory neurons, we analyzed RNA extracted from cultured E14 mouse MGE- and CTX-derived neurons (DIV 10) after these cultures were membrane-depolarized for 0, 1 and 6 hrs with 55mM extracellular KCl. To identify the gene ...
ORGANISM(S): Mus musculus 
2015-06-04 | E-GEOD-55588 | biostudies-arrayexpress
TranscriptomicsTranscription Factor Network Specifying Inhibitory versus Excitatory Neurons in the Dorsal Spinal Cord [RNA-Seq]
The proper balance of excitatory and inhibitory neurons is crucial to normal processing of somatosensory information in the dorsal spinal cord. Two neural basic helix-loop-helix transcription factors, Ascl1 and Ptf1a, are essential for generating the correct number and sub-type of neurons in multipl...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-55831 | biostudies-arrayexpress
ProteomicsNeuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons
In this study, we have applied cell type-specific in vivo biotinylation of proteins (CIBOP) to label Camk2a excitatory neuronal proteomes, and imposed differential centrifugation to prepare synaptosome-enriched fractions, followed by proteomic analysis of biotinylated neuronal proteins. This approac...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-13 | PXD068874 | Pride
Mitochondria Excitatory neuron Neuroinflammation Synapse vulnerability Alzheimer's disease Cognitive resilience Mapk signaling Native-state proteomics Synaptosome 
ProteomicsSecretome protein enrichment with click sugars (SPECS) analysis on primary neurons cultured from embryos derived from pregnant mice treated with or without valproic acid
Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired social communication and repetitive behaviors. In recent years, a pharmacological mouse model of ASD involving maternal administration of valproic acid (VPA) has become widely used. Newborn pups in this model show a...
ORGANISM(S): Mus Musculus (mouse) 
2024-10-26 | PXD042099 | JPOST Repository
GenomicsIndividual Human Cortical Progenitors Can Produce Excitatory and Inhibitory Neurons
Individual Human Cortical Progenitors Can Produce Excitatory and Inhibitory Neurons
PRJNA777693 | ENA
ProteomicsGlobal proteome of Atg5flox:CamKIIα-Cre:tdTomato FACS sorted WT and KO neurons
The experiment was performed to identify autophagy targets in wildtype and autophagy-deficient forebrain excitatory neurons. Therefore, neurons were isolated from the cortex, hippocampus and striatum of 2-3 weeks old Atg5flox/flox:CamKIIα-Cretg/wt:tdTomato+ (KO) and Atg5wt/wt:CamKIIα-Cretg/wt:tdToma...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD031552 | Pride
Atg5 ko In-vivo proteome Neurons Autophagy 
GenomicsNeuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
PRJNA543517 | ENA
TranscriptomicsIsolation of a Novel Rat Neural Progenitor Clone that Expresses Dlx Family Transcription Factors and Gives Rise to Functional GABAergic Neurons in Culture
GABAergic interneurons are lost in conditions including epilepsy and CNS injury, but there are few culture models available to study their function. Towards the goal of obtaining renewable sources of GABAergic neurons, we used the molecular profile of a functionally-incomplete GABAergic precursor c...
ORGANISM(S): Rattus norvegicus 
2011-11-09 | E-GEOD-31635 | biostudies-arrayexpress
GenomicseIF2α pathway controls memory consolidation via excitatory and somatostatin inhibitory neurons
eIF2α pathway controls memory consolidation via excitatory and somatostatin inhibitory neurons
PRJNA640593 | ENA
TranscriptomicsExpression data from adult rat tail MNs after spinal cord transection
Spinal cord injury leads to impaired motor and sensory functions. After spinal cord injury there is a an initial phase of hypo-reflexia followed by a developing hyper-reflexia, often termed spasticity. Previous studies have suggested a relationship between the reappearence of plateau potentials in m...
ORGANISM(S): Rattus norvegicus 
2009-10-31 | E-GEOD-16710 | biostudies-arrayexpress
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