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ProteomicsProteomic study of exfoliation syndrome
We provided a comprehensive plasma proteome analysis and expanded the profile of human plasma proteome. The differential plasma proteomic analysis of age-related cataract and exfoliation syndrome with/without glaucoma indicated that plasma proteome can reflect the pathophysiological situation of dis...
ORGANISM(S): Homo Sapiens 
2025-03-17 | PXD061945 |
ProteomicsCompositional analysis of extracellular aggregates in the eyes of patients with exfoliation syndrome and exfoliation glaucoma.
Exfoliation syndrome (XFS) is a condition characterized by the production of insoluble fibrillar aggregates (exfoliation material; XFM) in the eye and elsewhere. Many patients with XFS progress to exfoliation glaucoma (XFG), a significant cause of global blindness. We used quantitative mass spectrom...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026764 | Pride
Human Exfoliation syndrome Shotgun proteomics Psr-ohsu Lens capsule Aqueous humor Tmt labeling Quantitative proteomics Exfoliation glaucoma 
GenomicsRisk Variants for Exfoliation Syndrome Modulate Antisense Promoter Activity Within the LOXL1 Locus
The goal of this study was to identify functional variants that play a role in exfoliation syndrome (XFS) pathogenesis. We sequenced the entire LOXL1 locus in 50 South African XFS cases and 50 matched controls. The most strongly associated variants in this dataset were found in a ~7kb region spannin...
ORGANISM(S): Homo sapiens 
2015-07-22 | E-GEOD-66877 | biostudies-arrayexpress
ProteomicsComparative shotgun proteomics of aqueous humor for cataract, glaucoma and pseudoexfoliation eye disorders.
The aim of this work was to characterize proteome of aqueous humor from subjects with various eye conditions such as cataract, glaucoma and pseudoexfoliation syndrome by high-resolution chromate-mass-spectrometry. Twenty nine human aqueous humor samples were processed by shotgun proteomics. Data was...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080838 | MassIVE
TranscriptomicsMicroarray analysis of iris gene expression in mice with mutations relevant to glaucoma
Several ocular diseases involve the iris, notably including oculocutaneous albinism, pigment dispersion syndrome, and exfoliation syndrome. To screen for candidate genes that may be active in these diseases, genome-wide iris gene expression patterns were comparatively analyzed from mouse models of t...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-16994 | biostudies-arrayexpress
GenomicsRisk Variants for Exfoliation Syndrome Modulate Antisense Promoter Activity Within the LOXL1 Locus
The goal of this study was to identify functional variants that play a role in exfoliation syndrome (XFS) pathogenesis. We sequenced the entire LOXL1 locus in 50 South African XFS cases and 50 matched controls. The most strongly associated variants in this dataset were found in a ~7kb region spannin...
ORGANISM(S): Homo sapiens 
2015-07-22 | GSE66877 | GEO
GenomicsHomo sapiens
NEI CIDR GWAS for Exfoliation Syndrome and Glaucoma
PRJNA306966 | ENA
GenomicsHomo sapiens
NEI CIDR GWAS for Exfoliation Syndrome and Glaucoma
PRJNA306967 | ENA
GenomicNEI Exfoliation Genotyping Study

The overall goal of our research is to elucidate the pathogenesis of exfoliation syndrome and the associated glaucoma, making it possible to implement effective screening and prevention strategies and to develop novel therapies. Cases genotyped for this project are from the Nurses Health Study (N...

phs001053 | dbGaP
UnknownAssociation of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.
Not available
S-EPMC7903258 | biostudies-literature
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