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TranscriptomicsUsing high-density exon arrays to profile gene expression in closely related species (Exon 1.0 ST)
Global comparisons of gene expression profiles between species provide significant insight into gene regulation, evolutionary processes, and disease mechanisms. In this work, we describe a flexible and intuitive approach for global expression profiling of closely related species, using high-density ...
ORGANISM(S): Pan troglodytes 
2009-05-04 | E-GEOD-15626 | biostudies-arrayexpress
TranscriptomicsUsing high-density exon arrays to profile gene expression in closely related species
This SuperSeries is composed of the following subset Series: GSE15626: Using high-density exon arrays to profile gene expression in closely related species (Exon 1.0 ST) GSE15665: Using high-density exon arrays to profile gene expression in closely related species (HJAY) Refer to individual Series
ORGANISM(S): Macaca mulatta 
2009-05-04 | E-GEOD-15666 | biostudies-arrayexpress
ProteomicsBiochemical and Structural Basif for Differential Inhibitor Sensitivity of EGFR with Distinct Exon 19 Mutaions
Tyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). We studied structural basis of differential TKI sensitivity among EGFR exon 19 mutants by HDX-MS.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037374 | Pride
Exon 19 Hdx-ms Egfr 
Proteomics,MultiomicsRaj_nSR100_interactions_P36_V21_P105_V17
This submission includes the mass spectrometry data for the manuscript by Raj et al. (nSR100 regulation of an exon network required for neurogenesis). This submission contains files for Srrm4 (aka nSR100) interactions from mouse N2A cells acquired on a 5600 TripleTOF mass spectrometer and files for...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2014-04-23 | MSV000078609 | MassIVE
TranscriptomicsExon Level Expression Profiling: a Novel Unbiased Transcriptome Analysis for Body Fluids
Transcriptome analysis of partially degraded and fragmented RNA samples from body fluids Global gene expression profiling has shown great promise in high-throughput biomarker discovery for early disease detection in body fluids such as saliva, which is accessible, cost-effective, and non-invasive. ...
ORGANISM(S): Homo sapiens 
2008-05-19 | E-GEOD-7760 | biostudies-arrayexpress
ProteomicsThe structural dynamics of EGFR exon 19 mutants
Tyrosine kinase inhibitors (TKIs) are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). TKI responses vary across tumors driven by the heterogeneous group of exon 19 deletions and mutations, but the mole...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037355 | Pride
Exon 19 Hdx-ms Egfr 
ProteomicsThe strutural dynamics of EGFR Exon 19 mutants
Tyrosine kinase inhibtors are used to treat non-small cell lung cancers (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain (TKD). We characterized the dynamics of purified EGFR exon 19 kinase domain mutants by HDX-MS with or withour erlotinib, one of th...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037448 | Pride
Hdx-ms Egfr Exon19 
TranscriptomicsMADS: a New and Improved Method for Analysis of Differential Alternative Splicing by Exon-tiling Microarrays
We describe a method, MADS (Microarray Analysis of Differential Splicing), for discovery of differential alternative splicing from exon tiling microarrays. MADS incorporates a series of low-level analysis algorithms motivated by the “probe-rich” design of exon arrays, including background correction...
ORGANISM(S): Mus musculus 
2008-05-09 | E-GEOD-11344 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially regulated splice variants and novel exons in glial brain tumors using exon arrays
Aberrant splice variants are involved in the initiation and/or progression of glial brain tumors. We therefore set out to identify splice variants that are differentially expressed between histological subgroups of gliomas. Splice variants were identified using a novel platform that profiles the exp...
ORGANISM(S): Homo sapiens 
2008-01-28 | E-GEOD-9385 | biostudies-arrayexpress
TranscriptomicsUsing high-density exon arrays to profile gene expression in closely related species (HJAY)
Global comparisons of gene expression profiles between species provide significant insight into gene regulation, evolutionary processes, and disease mechanisms. In this work, we describe a flexible and intuitive approach for global expression profiling of closely related species, using high-density ...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-15665 | biostudies-arrayexpress
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