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ProteomicsThe EXOSC10S402T allele identified in colon cancer causes early embryonic lethality and suggests EXOSC10 as a biomarker for 5-fluorouracil sensitivity
The conserved 3’-5’ exoribonuclease EXOSC10/Rrp6 degrades and processes aberrant mRNAs and non-coding RNAs in cooperation with the RNA exosome. The protein is phosphorylated and ubiquitinated and it’s subcellular localization and stability are controlled during stress responses via sumoylation and t...
ORGANISM(S): Homo sapiens (Human) 
2026-03-20 | PXD061578 | Pride
Rrp6 5-fluorouracil Exosc10 Ubiquitination 
ProteomicsInactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice.
EXOSC10 is a catalytic subunit of the nuclear RNA exosome with an exoribonuclease activity. The enzyme processes and degrades different classes of RNAs. To delineate the role of EXOSC10 during oocyte growth, specific Exosc10 inactivation was performed in the oocytes from the primordial follicle stag...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD039417 | Pride
Oogenesis Exosc10 Follicular development Ovary 
GenomicsRNA binding by Exosc10 in the developing mouse cortex
RNA binding by Exosc10 in the developing mouse cortex
PRJNA689478 | ENA
GenomicsHypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile
Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile
PRJNA956549 | ENA
UnknownCooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.
Not available
S-EPMC4793216 | biostudies-literature
ProteomicsThe Ubiquitin-Specific Protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
The RNA exosome is an essential 3’ to 5’ processing exoribonuclease complex that mediates degradation, processing, and quality control of virtually all eukaryotic RNAs. The nucleolar RNA exosome, consisting of a 9-subunit core and a distributive 3ʹ to 5ʹ exonuclease EXOSC10, plays a critical role in...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD031592 | Pride
Human Deubiquitination Sumoylation Usp36 Ribosome biogenesis Rna exosome 
GenomicsRNA-seq of shRNA-mediated EXOSC10 and XRN2 knockdown
RNA-seq of shRNA-mediated EXOSC10 and XRN2 knockdown
PRJNA541843 | ENA
OtherRNA binding by Exosc10 in the developing mouse cortex
In our RIP-seq experiment, RNAs were purified from the E12.5 WT mouse cortex. By sequencing of the Exosc10-bound RNAs, binding enrichment of Exosc10 on 3159 transcripts was identified (adjusted p-value < 0.05). GO analysis revealed that the Exosc10-bound transcripts participate in various processes ...
ORGANISM(S): Mus musculus 
2021-01-20 | GSE164188 | GEO
UnknownHypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile.
Not available
S-EPMC10817850 | biostudies-literature
GenomicsThe alterations of gene expression profiling induced by EXOSC10-AS1 knockdown in HCT116 cells.
The alterations of gene expression profiling induced by EXOSC10-AS1 knockdown in HCT116 cells.
PRJNA1221911 | ENA
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