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MetabolomicsUntargeted and Targeted Plasma Metabolomics Analysis Identifies Aberrant Amino Acid Metabolism in Early Primary Angle-Closure Glaucoma

Purpose: To explore the plasma metabolite profiles of patients with early primary angle-closure glaucoma (PACG) and investigate their relevance to ocular characteristics and retinal-associated parameters.

Methods：Plasma samples were obtained from 30 early PACG patients and 30 healthy contro...

2026-01-06 | MTBLS13608 | MetaboLights
ProteomicsRetinal proteomic profiling in the course of experimental glaucoma
Intraocular pressure was elevated through episkleral vein occlusion by thermic cauterization of SD rats. Animals were further sacrificed after different periods of elevated IOP and the retinal proteins were investigated for alterations regarding the relative protein level in this experimental model ...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081757 | MassIVE
TranscriptomicsGlobal gene expression changes in rat retinal ganglion cells after experimental glaucoma
Goals of the study: 1. Assess the gene expression profile in rat RGC after experimental IOP elevation to elucidate the molecular mechanisms of RGC death. 2. Identify potentially novel genes and pathways that may contribute to RGC death in glaucoma. Background: Glaucoma is a neurodegenerative diseas...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-12596 | biostudies-arrayexpress
TranscriptomicsmiRNA microarray of human aqueous humor and lens capsule with glaucoma
A miRNA PCR array comprising 84 miRNAs was used to analyze the AH (glaucoma, n=3; control, n=3) and LC samples (glaucoma, n=3; control, n=4). Expression levels of 19 and 3 miRNAs were significantly upregulated in the AH and LC samples of the glaucoma group, respectively (p < 0.05).
ORGANISM(S): Homo sapiens 
2024-02-16 | E-MTAB-13771 | biostudies-arrayexpress
ProteomicsRetinal proteomic profiling in the course of experimental glaucoma
Intraocular pressure was elevated through episkleral vein occlusion by thermic cauterization of SD rats. Animals were further sacrificed after different periods of elevated IOP and the retinal proteins were investigated for alterations regarding the relative protein level in this experimental model ...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-04-11 | PXD005258 | Pride
Proteomics Glaucoma Retina Ocular hypertension Crystallins 
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
TranscriptomicsTranscription profiling of human optic nerve head astrocytes from normal and glaucoma patients
Astrocytes from optic nerve head from donors with and without glaucoma
ORGANISM(S): Homo sapiens 
2007-08-21 | E-GEOD-2378 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human trabecular meshwork cells to investigate the molecular mechanisms by which MYOC mutants cause glaucoma
Comparison of human trabecular meshwork transcriptomes of cells glaucoma-linked MYOC mutant Q368X
ORGANISM(S): Homo sapiens 
2012-10-06 | E-MEXP-3427 | biostudies-arrayexpress
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-21 | PXD007751 | Pride
Experimental glaucoma  alpha-crystallin b  neuroprotection  proteomics 
ProteomicsA monoclonal anti-HMGB1 antibody attenuates neurodegeneration in an experimental animal model of glaucoma
Neuroinflammation is a crucial process for the loss of retinal ganglion cells (RGC), a major characteristic of glaucoma. High expression of high mobility group box protein 1 (HMGB1) plays a detrimental role in inflammatory processes and is elevated in the retinas of glaucoma patients. Therefore, thi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD031987 | Pride
Glaucoma Discovery proteomics Neuroprotection Microarray Antibodies Neurodegeneration Animal model 
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