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TranscriptomicsA Basic Domain in the Histone H2B N-terminal Tail is Important for Nucleosome Assembly by FACT
Nucleosome assembly in vivo requires assembly factors, such as histone chaperones, to bind to histones and mediate their deposition onto DNA. In yeast, the essential histone chaperone FACT (FAcilitates Chromatin Transcription) functions in nucleosome assembly and H2A-H2B deposition during transcript...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-10 | E-GEOD-80831 | biostudies-arrayexpress
ProteomicsFACT, PAF-C, and CKII
Protein-protein interaction analysis for RNA Polymerase II and its elongation factors including: the PAF Complex, the FACT Complex, casein kinase II, DSIF, and TFIIF. These studies also characterized a number of casein kinase II phosphorylation sites on the subunits of the PAF Complex.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2015-07-20 | MSV000079197 | MassIVE
TranscriptomicsFACT and Spt6 Prevent Cryptic Transcription by Impeding H2A.Z Loading in Gene Bodies
H2A.Z is a highly conserved histone variant involved in several key nuclear processes. It is incorporated into promoters by SWR-C-related chromatin remodeling complexes, but whether it is also actively excluded from non-promoter regions is not clear. Here, we provide genomic and biochemical evidence...
ORGANISM(S): Saccharomyces cerevisiae 
2015-05-12 | E-GEOD-62880 | biostudies-arrayexpress
ProteomicsPyruvate facilitates FACT-mediated γH2AX loading to chromatin and promotes the radiation resistance of glioblastoma
DNA repair confers the resistance of tumor cells to DNA-damaging anticancer therapies, while how reprogrammed metabolism in tumor cells contributes to such process remains poorly understood. Pyruvate kinase M2 isoform (PKM2) catalyzes the conversion of phosphoenolpyruvate to pyruvate and regulates t...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2021-11-18 | PXD029790 |
GenomicsFACT Complex Recruitment and the Role of H2A.Z in Transcriptional Regulation
FACT Complex Recruitment and the Role of H2A.Z in Transcriptional Regulation
PRJNA1370064 | ENA
GenomicsFACT Complex Recruitment and the Role of H2A.Z in Transcriptional Regulation [ChIP-seq]
FACT Complex Recruitment and the Role of H2A.Z in Transcriptional Regulation [ChIP-seq]
PRJNA1272464 | ENA
GenomicsFACT Complex Recruitment and the Role of H2A.Z in Transcriptional Regulation [RNA-seq]
FACT Complex Recruitment and the Role of H2A.Z in Transcriptional Regulation [RNA-seq]
PRJNA1272465 | ENA
ProteomicsThe CENP-T/-W complex is a binding partner of the histone chaperone FACT
The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W is not inherited at centromeres and new deposition is absolutely required at...
ORGANISM(S): Homo sapiens (Human) 
2016-06-14 | PXD004099 | Pride
Centromere Cenp Mitosis Histone chaperone 
GenomicsTherapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (ChIP-Seq)
Therapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (ChIP-Seq)
PRJNA802206 | ENA
ProteomicsN-terminus of Spt16 anchors FACT to Mcm2 for parental histone recycling
Parental histone recycling is essential for the restoration of chromatin-based epigenetic information during chromatin replication; however, the specific mechanisms underlying the local recycling of parental histones remain poorly understood. Here, we reveal an unexpected role of the Spt16-N domain ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-26 | PXD043392 | Pride
Mcm2-7 Fact，parental histone recycling 
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