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TranscriptomicsDNA profiling of serous ovarian and Fallopian tube carcinomas with array CGH and MLPA
Primary serous ovarian carcinoma (OVCA) and serous Fallopian tube carcinoma (FTC), both belonging to the BRCA-linked tumour spectrum, share many properties and are treated similarly. However, a detailed molecular comparison has been lacking. We hypothesized that comparative genomic studies of serous...
ORGANISM(S): Homo sapiens 
2008-07-08 | E-GEOD-12040 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of differentially expressed genes in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies
Mutations in BRCA1 and BRCA2 genes confer an increased lifetime risk for breast and ovarian cancer. Ovarian cancer risk can be decreased by risk-reducing salpingo-oophorectomy (RRSO). Studies on RRSO material have altered the paradigm of serous ovarian cancer pathogenesis. The purpose of this study ...
ORGANISM(S): Homo sapiens 
2015-02-28 | E-GEOD-66387 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human non-malignant fallopian tube epithelium and high grade serous carcinoma.
The purpose of this study was to identify molecular alterations potentially involved in predisposition to adnexal serous carcinoma (SerCa) in the non-malignant fallopian tube epithelium (FTE) of BRCA1/2-mutation carriers, given recent evidence implicating the distal FTE as a common source for SerC...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-10971 | biostudies-arrayexpress
TranscriptomicsWhy nicotine is BAD for your Fallopian tube: an explanation for the association between smoking and ectopic pregnancy
Why nicotine is BAD for your Fallopian tube: an explanation for the association between smoking and ectopic pregnancy
ORGANISM(S): Homo sapiens 
2014-08-01 | E-MTAB-1290 | biostudies-arrayexpress
TranscriptomicsExpression data from non-malignant fallopian tube epithelium
Microarrays were used to examine gene expression changes that may be present in the fallopian tube epithelium of morphologically normal BRCA1 mutation positive and negative subjects. Fallopian tube epithelia has been implicated as an early point of origin for serous carcninoma. By examining the earl...
ORGANISM(S): Homo sapiens 
2011-04-28 | E-GEOD-28044 | biostudies-arrayexpress
ProteomicsFallopian tube secreted proteins affect ovarian metabolites in high grade serous ovarian cancer
Data files from Q Exactive were imported into Proteome Discoverer (version 2.2, Thermo Fisher) and analyzed using a label-free quantitation method. For MOE PTENshRNA protein IDs, MOE PTENshRNA results were compared to MOE SCRshRNA results against a Mus musculus database (10090_20160912 fasta file) a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-07-11 | MSV000089866 | MassIVE
TranscriptomicsGene expression analysis of ovarian tumors from mice with knockout of DICER and PTEN
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-28720 | biostudies-arrayexpress
TranscriptomicsProgesterone-mediated effects on gene expression in mouse fallopian tube
The fallopian tube transports the gametes to the fertilization site and delivers the embryo to the uterus at the optimal time for implantation. Progesterone and the classical progesterone receptor (PGR) are known to be involved in regulating both tubal ciliary beating and muscular contractions, poss...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-61407 | biostudies-arrayexpress
ProteomicsProfiling of the human Fallopian tube matrisome
Characterization of the protein composition of the extracellular matrix (ECM) of normal human Fallopian tube samples.
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD023707 | Pride
Extracellular matrix Fallopian tube Bottom-up proteomics 
TranscriptomicsGene expression analysis of human serious ovarian tumors and fimbria control
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-28721 | biostudies-arrayexpress
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