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TranscriptomicsGenome-wide DNA methylation in normal and IUGR pancreatic islets
Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-16839 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Chronic kidney disease
Epidemiological studies indicate that adverse intrauterine and postnatal environment has a long-lasting role in chronic kidney disease (CKD) development. Epigenetic information can represent a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine meth...
ORGANISM(S): Homo sapiens 
2013-07-18 | E-GEOD-48944 | biostudies-arrayexpress
GenomicsCytosine methylation data generated by HELP-tagging from human osteosarcoma biopsy samples
Osteosarcoma is the most common primary malignant bone tumor in children. Validated markers for disease prognosis available at diagnosis are lacking. No genome-wide DNA methylation studies linked to clinical outcomes have been reported in osteosarcoma. To address this, we tested the methylome at ...
ORGANISM(S): Homo sapiens 
2015-01-18 | E-GEOD-59200 | biostudies-arrayexpress
TranscriptomicsA restricted repertoire of cytosine methylation changes in neonates following intrauterine growth restriction
Perturbations of the intrauterine environment can affect fetal development during critical periods of plasticity, and can increase susceptibility to a number of age-related diseases (e.g. type 2 diabetes mellitus; T2DM), manifesting sometimes decades later. We hypothesized that this biological memo...
ORGANISM(S): Homo sapiens 
2010-02-17 | E-GEOD-17727 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation in paired lung tumor/non-tumor samples using the HELP assay
In lung cancer, hypermethylation of specific gene promoters has been found during the progressive carcinogenesis. The identification of common methylation events will aid in the understanding of molecular events during neoplastic transformation and help develop biomarkers for cancer with high predic...
ORGANISM(S): Homo sapiens 
2012-03-31 | E-GEOD-35520 | biostudies-arrayexpress
TranscriptomicsLATE-REPLICATING HETEROCHROMATIN IS CHARACTERISED BY DECREASED CYTOSINE METHYLATION IN THE HUMAN GENOME (expression)
Heterochromatin is believed to be associated with increased levels of cytosine methylation. With the recent availability of genome-wide, high-resolution molecular data reflecting cytosine methylation or heterochromatic organization, such relationships can be explored systematically. As a well-defi...
ORGANISM(S): Homo sapiens 
2011-08-05 | E-GEOD-27518 | biostudies-arrayexpress
TranscriptomicsMethylation profiles of Chronic kidney disease
Epidemiological studies indicate that adverse intrauterine and postnatal environment has a long-lasting role in chronic kidney disease (CKD) development. Epigenetic information can represent a plausible carrier for mediating this "programming" effect. Here we demonstrate that genome-wide c...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-49557 | biostudies-arrayexpress
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