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UnknownSCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
Not available
S-EPMC4884786 | biostudies-literature
UnknownFBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia.
Not available
S-EPMC9308218 | biostudies-literature
UnknownFbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.
Not available
S-EPMC7320043 | biostudies-literature
UnknownLipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron.
Not available
S-EPMC5665448 | biostudies-literature
UnknownRTN4 and FBXL17 Genes are Associated with Coronary Heart Disease in Genome-Wide Association Analysis of Lithuanian Families.
Not available
S-EPMC4001410 | biostudies-literature
TranscriptomicsCrosstalk Between Acetylation and Ubiquitination Contributes to PRMT1 methyltransferase Homeostasis
PRMT1 plays pivotal roles in normal and disease biology. Understanding its regulation is crucial for therapeutic targeting. We demonstrate that p300-mediated acetylation of PRMT1 at K228 triggers degradation via FBXL17-dependent ubiquitination at K145. Using mass spectrometry, cellular biochemistry,...
ORGANISM(S): Homo sapiens 
2026-07-31 | GSE304181 | GEO
ProteomicsDual BACH1 regulation by complementary SCF-type E3 ligases
BACH1, FBXO22, FBXL17, oxidative stress response, E3, Cullin-RING ligases, F-box, cysteine modification, S-nitrosylation, heme
ORGANISM(S): Homo sapiens (Human) 
2024-12-03 | PXD051074 | Pride
Fbxl17 S-nitrosylation Fbxo22 Heme Oxidative stress response Cullin-ring ligases Bach1 E3 Cysteine modification F-box 
UnknownStructural basis for dimerization quality control.
Not available
S-EPMC8024055 | biostudies-literature
Genomics
6 months old medaka testis
PRJNA1477667 | ENA
ProteomicsDistinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress
Ubiquitin-dependent proteolysis regulates diverse cellular functions with high substrate specificity. The precision of this regulatory mechanism hinges on the ability of ubiquitin E3 ligases to decode the targets’ degradation signals, i.e. degrons, which canonically present as short linear motifs. H...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD053923 | Pride
Oxidative stress Ubiquitination Protein degradation Ubiquitin ligase Bach1 Fbxl17 Transcription repressor Fbxo22 Btb domain Scf Degron Cryo-em Hdx-ms 
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