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GenomicsEffect of Fbxo22 on ER and SRC-3 recruitment to the genomic loci
Effect of Fbxo22 on ER and SRC-3 recruitment to the genomic loci
PRJNA490048 | ENA
GenomicsTargeting FBXO22 enhances radiosensitivity of non-small cell lung cancer by inhibiting FOXM1/Rad51 axis
Targeting FBXO22 enhances radiosensitivity of non-small cell lung cancer by inhibiting FOXM1/Rad51 axis
PRJNA985761 | ENA
ProteomicsFBXO22 as an E3 ligase supporting targeted protein degradation
Targeted protein degradation (TPD) represents a potent chemical biology paradigm that leverages the cellular degradation machinery to pharmacologically eliminate specific proteins of interest. Although multiple E3 ligases have been discovered to facilitate TPD, there exists a compelling requirement ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-17 | PXD050270 | Pride
Human Ap-ms Abpp Global proteomics Fbxo22 
TranscriptomicsTargeting FBXO22 enhances radiosensitivity of non-small cell lung cancer by inhibiting FOXM1/Rad51 axis
FBXO22 is the substrate recognition subunit of SCF E3 ubiquitin ligase, which plays an important role in the occurrence, development and therapeutic response of solid tumors.At present, the relationship between FBXO22 and radiosensitivity of lung cancer has not been fully elucidated.Here we present ...
ORGANISM(S): Homo sapiens 
2024-02-07 | GSE235374 | GEO
GenomicsEffect of Fbxo22 on ER and SRC-3 recruitment to the genomic loci
The agonistic/antagonistic bio-character of selective estrogen receptor modulators (SERMs) can have therapeutic advantages, particularly in the case of premenopausal breast cancers. Although the contradictory effects of these modulators have been studied in terms of cross-talk between estrogen recep...
ORGANISM(S): Homo sapiens 
2018-12-26 | GSE119702 | GEO
ProteomicsDual BACH1 regulation by complementary SCF-type E3 ligases
BACH1, FBXO22, FBXL17, oxidative stress response, E3, Cullin-RING ligases, F-box, cysteine modification, S-nitrosylation, heme
ORGANISM(S): Homo sapiens (Human) 
2024-12-03 | PXD051074 | Pride
Fbxl17 S-nitrosylation Fbxo22 Heme Oxidative stress response Cullin-ring ligases Bach1 E3 Cysteine modification F-box 
UnknownGlobal identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis.
Not available
S-EPMC8738747 | biostudies-literature
UnknownRecruitment of FBXO22 for targeted degradation of NSD2.
Not available
S-EPMC11581931 | biostudies-literature
UnknownSCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.
Not available
S-EPMC4754341 | biostudies-literature
UnknownFBXO22 degrades nuclear PTEN to promote tumorigenesis.
Not available
S-EPMC7136256 | biostudies-literature
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