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ProteomicsIdentification of mouse FcRn-specific vesicles in wild type and FcRn knockout podocytes
mouse podocytes overexpressing FcRn splice variants 1-5 were used to isolated FcRn-specific vesicles to identify the contents of those vesicles that are different from Rab5, 7, & 11 vesicles
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD045572 | Pride
Mouse Podocytes Fcrn Vesicles 
TranscriptomicsTranscription profiling of mouse Podocytes reveal use of FcRn to clear IgG from the glomerular basement membrane
The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the glomerular basement membrane (GBM). Here we provide evidence that an active transport mechanism exists t...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10017 | biostudies-arrayexpress
ProteomicsInvestigation of the FcRn:IgG interaction by HDX-MS
Immunoglobulin Gs (IgGs) have become highly successful drug scaffolds by combining very specific target binding with the ability to induce cellular cytotoxicity. Of further advantage, IgGs possess unusually long half-lives in the blood (2-3 week). IgGs achieve such extraordinary half-lives through a...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD044285 | Pride
Ms  protein-protein interaction  mass spectrometry Hdx-ms 
TranscriptomicsPodocytes use FcRn to clear IgG from the glomerular basement membrane
The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the glomerular basement membrane (GBM). Here we provide evidence that an active transport mechanism exists t...
ORGANISM(S): Mus musculus 
2008-01-01 | GSE10017 | GEO
UnknownDifferential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin.
Not available
S-EPMC11141909 | biostudies-literature
UnknownIdentification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.
Not available
S-EPMC11012118 | biostudies-literature
UnknownMegalin Orchestrates FcRn Endocytosis and Trafficking.
Not available
S-EPMC9818419 | biostudies-literature
UnknownSelection of bispecific antibodies with optimal developability using FcRn‑Ph‑HPLC as an optimized FcRn affinity chromatography method.
Not available
S-EPMC10443974 | biostudies-literature
UnknownDissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies.
Not available
S-EPMC4059163 | biostudies-literature
UnknownIdentification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation.
Not available
S-EPMC12162884 | biostudies-literature
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