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ProteomicsFe-S clusters-binding proteins in mitoribosome
The human mitochondrial ribosome contains three [2Fe-2S] clusters whose assembly pathway, role, and implications for mitochondrial and metabolic diseases are unknown. Here, structure-function correlation studies show that the clusters play structural roles during mitoribosome assembly. To uncover th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039321 | Pride
Fe-s cluster Mitoribosome 
ProteomicsMonitoring Fe-S cluster occupancy across the E. coli proteome using chemoproteomics
Iron-sulfur (Fe-S) clusters are ubiquitous metallocofactors involved in redox chemistry, radical generation, and gene regulation. Common methods to monitor Fe-S clusters include spectroscopic analysis of purified proteins, and auto-radiographic visualization of radiolabeled iron distribution in prot...
ORGANISM(S): Escherichia coli 
2024-05-22 | PXD026488 | Pride
Redime Iron-sulfur clusters Isotop-abpp E. coli 
ProteomicsMETTL17 is an Fe-S cluster checkpoint for mitochondrial translation
Friedreich’s ataxia (FA) is the most common monogenic mitochondrial disease. FA is caused by a depletion of the mitochondrial protein frataxin (FXN), an iron-sulfur (Fe-S) cluster biogenesis factor. To better understand the cellular consequences of FA, we performed quantitative proteome profiling of...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD045443 | Pride
Mettl17 Friedreich’s ataxia Fxn Fe-s clusters 
ProteomicsFeS protein levels in Arabidopsis plants expressing a mutated NEET protein
Iron-sulfur (Fe-S) clusters play an essential role in plants as protein co-factors mediating diverse electron transfer reactions. Because they can react with oxygen to form reactive oxygen species (ROS) and cause cellular damage, the biogenesis of Fe-S clusters is highly regulated. A newly discovere...
ORGANISM(S): Arabidopsis Thaliana 
2021-01-24 | PXD015447 | panorama
ProteomicsE. coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress  
Iron-sulfur (Fe-S) clusters are required for essential biological pathways, including respiration and isoprenoid biosynthesis. Complex Fe-S cluster biogenesis systems have evolved to maintain an adequate supply of this critical protein cofactor. In Escherichia coli, two Fe-S biosynthetic systems, th...
ORGANISM(S): Escherichia coli 
2024-07-13 | PXD053317 | Pride
Iron-sulfur (fe-s) protein Monothiol glutaredoxin grxd A-type carrier erpa Mass spectrometry (ms) E. coli Chemoproteomics Iron metabolism Metal homeostasis 
ProteomicsIron-Regulated Assembly of the Cytosolic Iron-Sulfur Cluster Biogenesis Machinery
The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway delivers Fe-S clusters to nuclear and cytosolic Fe-S proteins involved in essential cellular functions. Although the delivery process is regulated by the availability of iron and oxygen, it remains unclear how CIA components orchestrate...
ORGANISM(S): Homo Sapiens 
2022-06-06 | PXD033557 | panorama
UnknownEmerging critical roles of Fe-S clusters in DNA replication and repair.
Not available
S-EPMC4576882 | biostudies-literature
ProteomicsDynamic Assembly of the Cytosolic Iron-Sulfur Cluster Biogenesis Machinery Requires Iron-Sulfur Cluster Incorporation of CIAO3
Cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway delivers Fe-S clusters to nuclear and cytosolic Fe-S proteins involved in essential cellular functions. This delivery process is regulated by availability of iron and oxygen, but it remains unclear how CIA components orchestrate the cluster...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088394 | MassIVE
UnknownReversible Alkyl-Group Migration between Iron and Sulfur in [Fe4S4] Clusters.
Not available
S-EPMC9526375 | biostudies-literature
ProteomicsThe plastidial Arabidopsis thaliana NFU1 delivers [4Fe-4S] clusters to specific client proteins
Proteins incorporating iron-sulfur (Fe-S) cofactors are required for a plethora of metabolic processes. Their maturation depends on three Fe-S cluster assembly machineries located in the cytosol, mitochondria and chloroplasts. After de novo formation on scaffold proteins, Fe-S centers are loaded on ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-07-06 | PXD015295 | Pride
Arabidopsis 
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