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ProteomicsChromID identifies the protein interactome at chromatin marks
Chromatin modifications instruct genome function through spatiotemporal recruitment of regulatory factors to the genome. However, how these modifications define the proteome composition at distinct chromatin states remains to be fully characterized. Here, we made use of natural protein domains as mo...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-30 | PXD017235 | Pride
Chromatin Systems biology Chromatin proteomics Epigenetics Synthetic biology 
ProteomicsHistone Modification Analysis of Oligodendroglioma and Astrocytoma Brain Cancer Samples
WHO classification for tumors of the central nervous system strongly endorses molecular tests for the precise diagnosis of diffuse gliomas. While alterations in the DNA methylation status of gliomas are already well documented and used in specialised clinical centers to distinguish between brain tum...
ORGANISM(S): Homo sapiens (Human) 
2020-01-17 | PXD015151 | Pride
Oligodendroglioma Histone modifications Brain cancer Astrocytoma Histone epi-proteome 
TranscriptomicsThe activation potential of MOF is constrained for dosage compensation
The H4K16 acetyltransferase MOF plays a crucial role in dosage compensation in Drosophila, but has additional, global functions. We compared the molecular context and effect of MOF in male and female flies combining chromosome-wide mapping and transcriptome studies with analyses of defined reporter ...
ORGANISM(S): Drosophila melanogaster 
2010-06-26 | E-GEOD-20695 | biostudies-arrayexpress
TranscriptomicsDifferential Chromatin Binding of the Drosophila Dosage Compensation Complex
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2012-12-11 | E-GEOD-37865 | biostudies-arrayexpress
ProteomicsDrosophila SWR1 and NuA4 complexes are defined by DOMINO isoform
Histone acetylation and deposition of H2A.Z variant are integral aspects of active transcrip-tion. In Drosophila, the single DOMINO chromatin regulator complex is thought to combine both activities via an unknown mechanism. Here we show that alternative isoforms of the DOMINO nucleosome remodeling A...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-05-27 | PXD017729 | Pride
Nua4 Drosophila Domino H3ac Swr1 H4ac 
UnknownReplacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader.
Not available
S-EPMC12091851 | biostudies-literature
TranscriptomicsChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells
ChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells MLE, MSL3 amd MOF ChIP in Drosophila S2 cells. 1-5 biological replicates per experiment. dye-swaps as indicated in sample description
ORGANISM(S): Drosophila melanogaster 
2012-12-11 | E-GEOD-37863 | biostudies-arrayexpress
UnknownA randomized, placebo-controlled trial of canakinumab in patients with peripheral artery disease.
Not available
S-EPMC6791746 | biostudies-literature
TranscriptomicsTranscription profiling of rat hippocampus from young and aged rats with age-related spatial learning impairments
The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris Water Maze and then isolated messenger RNA from...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3531 | biostudies-arrayexpress
ProteomicsProtein acetylation in young versus midlife Drosophila male heads
Old age is associated with a progressive decline of mitochondrial function and changes in nuclear chromatin. However, little is known about how metabolic activity and epigenetic modifications change as organisms reach their midlife. Here, we assessed how protein acetylation changes during midlife in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-01-22 | PXD003318 | Pride
Ageing Drosophila Protein acetylation 
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