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ProteomicsQuantitative proteomic analysis of urinary exosomes from patients with primary aldosteronism that underwent fludrocortisone suppression test
The sodium chloride cotransporters (NCC) and the epithelial sodium channel (ENaC) have been reported to be the main effectors of aldosterone in Na+ and Cl- reabsorption in the distal nephron and dietary K+ downregulates NCC. The Cl-/HCO3- exchanger pendrin has been revealed as a key role in maintain...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD017083 | Pride
Human Exosomes Urine Kidney 
ProteomicsQuantitative proteome of urinary extracellular vesicles (uEVs) from hypertensive patients with raised aldosterone-to-renin ratios (ARRs) that underwent seated saline suppression testing (SSST)
This dataset contains quantitative proteome from Tandem Mass Tag (TMT) based quantitative proteomic analysis on uEVs from hypertensive patients with raised aldosterone-to-renin ratios (ARR) that underwent seated saline suppression testing (SSST).
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD022653 | Pride
Human Urine Urinary extracellular vesicle Kidney 
ProteomicsAcute effects of Salbutamol in Mouse Kidney Distal Convoluted Tubules (mpkDCT) Cells
The sympathetic nervous system (SNS) plays a central role in blood pressure regulation. Recent studies have shown that cells of the distal convoluted tubule (DCT) can be stimulated directly via the beta-adrenergic receptor resulting in activation of the NaCl cotransporter NCC. Whether these effects ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-17 | PXD019051 | Pride
Beta2-adrenergic receptor Salbutamol Hypertention Dct 
ProteomicsEffects of the differential K+ diets on mouse kidney cortex tissue
In this project, we investigated the global proteome alteration in mouse kidney cortex tissues after differential K+ diet treatments. TMTpro labeling strategy was used to obtain protein quantification information from LC-MS based proteomic analysis.
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD035354 | Pride
Potassium Mouse Kidney 
ProteomicsComparative proteomic analysis of kidney distal convoluted tubule and cortical collecting duct cells following long-term hormonal stimulation
The distal convoluted tubule (DCT) and the cortical collecting ducts (CCD) are portions of renal tubule that are partly responsible for maintaining the systemic concentrations of potassium, sodium, calcium and magnesium. Despite being structurally similar, DCT and CCD cells have different transport ...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-15 | PXD005454 | Pride
Distal convoluted tubule Mouse Hormone Kidney Cortical collecting duct Long-term 
UnknownExpression and function of the lipocalin-2 (24p3/NGAL) receptor in rodent and human intestinal epithelia.
Not available
S-EPMC3734285 | biostudies-literature
UnknownDevelopment of a selective and scalable N1-indazole alkylation.
Not available
S-EPMC10877319 | biostudies-literature
ProteomicsProteomic profiling of ubiquitylated proteins in urinary exosomes
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated, but that ubiquitin is cleaved by specific...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080269 | MassIVE
UnknownGenetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium.
Not available
S-EPMC6945596 | biostudies-literature
UnknownGenetic deletion of the kidney sodium/proton exchanger-3 (NHE3) does not alter calcium and phosphate balance due to compensatory responses.
Not available
S-EPMC12939918 | biostudies-literature
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