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MetabolomicsPseudorabies Virus Triggers Ferritinophagy-Mediated Ferroptosis and Neuroinflammation in Viral Encephalitis

Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, primarily infects pigs and poses a significant threat to the swine industry. In recent years, emerging PRV variants have been reported to infect humans, predominantly causing encephalitis. Ferroptosis is a recently identified...

2026-04-17 | MTBLS12373 | MetaboLights
ProteomicsNCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
Oncogenic KRAS rewires pancreatic ductal adenocarcinoma (PDAC) metabolism to promote dependence on autophagy and iron metabolism. NCOA4-mediated ferritinophagy links autophagy and iron metabolism as NCOA4 selectively targets ferritin, the cellular iron storage complex, via autophagy to the lysosome ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-17 | PXD033356 | Pride
Ferritinophagy Ncoa4 Iron Pdac 
ProteomicsLysosomal storage disease proteo/lipidomic profiling using nMOST links ferritinophagy with mitochondrial iron deficiencies in cells lacking NPC2
Lysosomal storage diseases (LSDs) comprised ~50 gene loci causing the accumulation of cellular material in the lysosome and associated defects in lysosomal function, but systematic molecular phenotyping is lacking. Here, we apply a nanoflow-based multi-omic single-shot technology (nMOST) workflow to...
ORGANISM(S): Homo sapiens (Human) 
2024-10-08 | PXD049336 | Pride
Ferritinophagy Multiplexed tmt proteomics Oxphos Lysosomal storage disorders Mitochondrial function 
GenomicsHepatokine ORM2 suppresses pathological ferritinophagy to prevent acute tissue injury
Hepatokine ORM2 suppresses pathological ferritinophagy to prevent acute tissue injury
PRJNA1162917 | ENA
GenomicsNcoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
PRJNA1224266 | ENA
GenomicsFerritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [9a]
Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [9a]
PRJNA984289 | ENA
GenomicsFerritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [scRNA-seq]
Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [scRNA-seq]
PRJNA984274 | ENA
TranscriptomicsHepatokine ORM2 suppresses pathological ferritinophagy to prevent acute tissue injury
Acute tissue injuries trigger rapid cellular damage, but cell-intrinsic protective programs attenuate pathology through regulatory axes. Here, we demonstrate that Orosomucoid 2 (ORM2), a hepatokine, is significantly upregulated during drug-induced acute liver injury. Knock out Orm2 exacerbates liver...
ORGANISM(S): Mus musculus 
2024-09-22 | GSE277619 | GEO
GenomicsFerritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [shCTL vs shNCOA4]
Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [shCTL vs shNCOA4]
PRJNA984273 | ENA
GenomicsFerritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [cycling and quiescent fractions]
Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells [cycling and quiescent fractions]
PRJNA984288 | ENA
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