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ProteomicsNCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
Oncogenic KRAS rewires pancreatic ductal adenocarcinoma (PDAC) metabolism to promote dependence on autophagy and iron metabolism. NCOA4-mediated ferritinophagy links autophagy and iron metabolism as NCOA4 selectively targets ferritin, the cellular iron storage complex, via autophagy to the lysosome ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-17 | PXD033356 | Pride
Ferritinophagy Ncoa4 Iron Pdac 
GenomicsNCOA4
NCOA4
PRJNA398076 | ENA
GenomicsEffect of NCOA4-depletion on the transcriptome profile of J774 mouse macrophage cells
Effect of NCOA4-depletion on the transcriptome profile of J774 mouse macrophage cells
PRJNA877228 | ENA
GenomicsNcoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
PRJNA1224266 | ENA
GenomicsWTAP Regulates NCOA4-Mediated Ferroptosis via a YTHDF2-Dependent Mechanism in Preeclampsia
WTAP Regulates NCOA4-Mediated Ferroptosis via a YTHDF2-Dependent Mechanism in Preeclampsia
PRJNA1292888 | ENA
TranscriptomicsTranscriptome profiling of human erythroblast cells knocking down NCOA4
Purpose: Knocking down NCOA4 disrupted Thyroid hormone receptor beta agonist,GC-1, mediated terminal human erythroblast differentiation. Therefore, we conducted RNA-seq to profile the transcriptome changes in NCOA4 knocked down human erythroblasts.. Methods: Human CD34+ cells were transduced by lent...
ORGANISM(S): Homo sapiens 
2017-09-06 | GSE102582 | GEO
GenomicsEffect of iron depletion on gene expression of NCOA4-deficient and control HT22 hippocampal neuron cells
Effect of iron depletion on gene expression of NCOA4-deficient and control HT22 hippocampal neuron cells
PRJNA872924 | ENA
TranscriptomicsEffect of NCOA4-depletion on the transcriptome profile of J774 mouse macrophage cells
To determine the physiological roles of NCOA4 and ferritinophagy in macrophages, NCOA4 was depleted via liposome-mediated siRNA delivery into cells. Cells were treated with siRNA for NCOA4 depletion and then the transcriptome profiles acquired from RNA-seq were compared with those of control (scramb...
ORGANISM(S): Mus musculus 
2022-09-30 | GSE212772 | GEO
TranscriptomicsEffect of iron depletion on gene expression of NCOA4-deficient and control HT22 hippocampal neuron cells
To determine the physiological roles of NCOA4 and NCOA4-mediated ferritinophagy in hippocampal neurons, NCOA4 was depleted using siRNA and desferrioxamine (DFO; 100 µM, 24 h) was added to restrict iron availability. Cells were treated for NCOA4 depletion, iron restriction, or both, and then the tran...
ORGANISM(S): Mus musculus 
2022-12-30 | GSE211931 | GEO
TranscriptomicsNcoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
TET2 is among the most commonly mutated genes in both clonal hematopoiesis and myeloid malignancies, thus, the ability to identify selective dependencies in TET2 deficient cells has broad translational significance. Here, we identify regulators of Tet2 knockout (KO) hematopoietic stem and progenitor...
ORGANISM(S): Mus musculus 
2025-06-01 | GSE289732 | GEO
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