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ProteomicsAntibody Characterisation using FFAP
Modern therapeutic approaches, especially for cancer and certain autoimmune disorders, evolved and have started to frequently rely on monoclonal antibodies (mAb) or other recombinantly prepared biomolecules (biopharmaceuticals) instead of on small molecules. The mAb treatment is effective but comes ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044326 | Pride
Covalent labeling Protein structure Mass spectrometry Ffap Togni agents 
UnknownStructural Characterization of Monoclonal Antibodies and Epitope Mapping by FFAP Footprinting.
Not available
S-EPMC11099888 | biostudies-literature
UnknownIn Vivo Effects of Free Form Astaxanthin Powder on Anti-Oxidation and Lipid Metabolism with High-Cholesterol Diet.
Not available
S-EPMC4532504 | biostudies-literature
ProteomicsFast Fluoroalkylation of Proteins Uncovers Structure and Dynamics of Biological Macromolecules
Stable covalent labeling of proteins in combination with mass spectrometry has been established as a complementary technique to classical structural methods, such as X Ray, NMR, or Cryo-EM used for protein structure determination. Although the current stable covalent labeling techniques enable to mo...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD027310 | Pride
Radical labeling Mass spectrometry Protein footprinting Conformational changes Fluoroalkylation Hyperva-lent iodine reagents Protein structure Togni reagents Protein fingerprinting Epitope mapping Protein surface mapping Radicals Proteomics Interactomics Trifluoromethylation 
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathwa...

2026-02-06 | MTBLS13859 | MetaboLights
MetabolomicsAlistipes putredinis Alleviates Metabolic-Associated Fatty Liver Disease via the Acetate-GPR43 Axis by Suppressing Neutrophil ROS Generation

Background & Aims:

Intestinal dysbiosis contributes to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), though precise bacterial targets and mechanisms remain incompletely elucidated. This study investigated whether the depletion of Alistipes putredinis (AP) in adol...

2026-01-15 | MTBLS13694 | MetaboLights
MetabolomicsAlistipes putredinis Alleviates Metabolic-Associated Fatty Liver Disease via the Acetate-GPR43 Axis by Suppressing Neutrophil ROS Generation

Background & Aims:

Intestinal dysbiosis contributes to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), though precise bacterial targets and mechanisms remain incompletely elucidated. This study investigated whether the depletion of Alistipes putredinis (AP) in adol...

2026-01-16 | MTBLS13699 | MetaboLights
UnknownBioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury.
Not available
S-EPMC11609671 | biostudies-literature
MetabolomicsEffect of probiotics intervention on short chain fatty acids in irradiated mice

In order to study the effect of probiotic intervention on short-chain fatty acids in irradiated mice, we collected feces, blood, and brain tissues from irradiated mice. The content of short-chain fatty acids was determined by High Performance Liquid Chromatography-mass spectrum. Further investiga...

2026-09-28 | MTBLS15754 | MetaboLights
MetabolomicsTargeted Metabolome of Caenorhabditis elegans

The effect of Lactiplantibacillus plantarum Q7 on SCFAs in Caenorhabditis elegans

2026-07-20 | MTBLS14034 | MetaboLights
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