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ProteomicsLabel-free mass spectrometry-based proteomics of lung cancer FFPE glass slides
Formalin-fixed, paraffin-embedded (FFPE) is the most common method for preserving tissue material in the clinic with millions of specimens stored in biobanks around the world. However, FFPE samples present challenges for molecular profiling, including proteomics. Nonetheless, optimized sample prepar...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD072014 | Pride
Dia Ffpe Label-free proteomics Tumor Lung cancer Lc-ms/ms 
UnknownA High-Throughput Workflow for FFPE Tissue Proteomics.
Not available
S-EPMC10326908 | biostudies-literature
ProteomicsA rapid workflow for high-throughput FFPE-based quantitative proteomics
Formalin-fixed, paraffin-embedded (FFPE) tissue samples are an invaluable resource to study the underlying molecular mechanisms of the diseases and when coupled with laser capture microdissection (LCM, isolation of sub histological regions of the tissue sections is readily obtained for further analy...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040727 | Pride
Ffpe Tandem mass spectrometry Kidney Lcm 
ProteomicsLabel-free mass spectrometry-based proteomics of lung cancer FFPE scrolls
Formalin-fixed, paraffin-embedded (FFPE) is the most common method for preserving tissue material in the clinic with millions of specimens stored in biobanks around the world. However, FFPE samples present challenges for molecular profiling, including proteomics. Nonetheless, optimized sample prepar...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD071948 | Pride
Dia Ffpe Label-free proteomics Tumor Lung cancer Lc-ms/ms 
ProteomicsASAP – Automated Sonication free Acid assisted Proteomes from cells & FFPE tissues
Formalin-fixed, paraffin-embedded (FFPE) tissues are an invaluable resource for retrospective studies but protein extraction and subsequent sample processing steps have shown to be challenging for mass spectrometry (MS) analysis. Streamlined high-throughput sample preparation workflows are essential...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD036910 | Pride
Pediatric tumors Trifluoroacetic acid Ffpe Sonication-free Clinical proteomics 
ProteomicsSystematic Evaluation and Optimization of Protein Extraction Parameters in Diagnostic FFPE Specimens
Objectives: Formalin-fixed paraffin-embedded (FFPE) tissue is the standard material for di-agnostic pathology but poses relevant hurdles to accurate protein extraction due to cross-linking and chemical alterations. While numerous extraction pro-tocols and chemicals have been described, systematic c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029133 | Pride
Protein extraction  formalin-fixed paraffin-embedded tissue  clinical prote-omics  antigen retrieval  crosslinking reversal  protein analysis  biomarker 
ProteomicsA streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis
Formalin fixation and paraffin-embedding (FFPE) is the most common method to preserve human tissue for clinical diagnosis and FFPE archives represent an invaluable resource for biomedical research. Proteins in FFPE material are stable over decades but their efficient extraction and streamlined analy...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD017269 | Pride
Biobank Ffpe Cancer Proteomics Tissue Mass spectrometry Protocol 
UnknownHYPERsol: High-Quality Data from Archival FFPE Tissue for Clinical Proteomics.
Not available
S-EPMC7515636 | biostudies-literature
ProteomicsQuantitative proteomics of FFPE-preserved cardiac specimens
Archival human heart tissue, preserved as formalin-fixed, paraffin-embedded (FFPE) samples in pathology collections worldwide, represents a largely untapped resource for cardiac proteomics. This study employs a comprehensive proteomic workflow optimized for human FFPE heart tissue and leverages pair...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD060216 | Pride
Human Ffpe Heart 
ProteomicsProteome profiling of FF and FFPE microdissected human kidney tissue
Aim of the project was to evaluate several MS-comaptible detergents for processing fresh frozen (FF) and formalin fixed paraffin embedded (FFPE) microdissected human kidney tissue. Here we have evaluated sensitivity of the methods and their applicability on FF and FFPE tissues, as well as investigat...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD020793 | Pride
Ff Ms-compatible protocols Mass spectrometry Ffpe Kidney 
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