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ProteomicsThe phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
Recurrent cancer-causing fusions of NUP98 produce higher-order assemblies known as condensates. How NUP98 oncofusion-driven condensates activate oncogenes remains poorly understood. Here, we investigate NUP98-PHF23, a leukemogenic chimera of the disordered FG-repeats-rich region of NUP98 and the H3K...
ORGANISM(S): Homo sapiens (Human) 
2024-12-31 | PXD056948 | Pride
H3k4me3 Leukemia Histone modification P300 Kmt2/mll Nup98 Wdr5 Fg repeats Condensate Chromatin 
UnknownImpact of distinct FG nucleoporin repeats on Nup98 self-association.
Not available
S-EPMC11076500 | biostudies-literature
UnknownNatively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex.
Not available
S-EPMC5992322 | biostudies-literature
GenomicsFG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [smallRNA-seq]
FG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [smallRNA-seq]
PRJNA1235205 | ENA
GenomicsFG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [RNA-seq]
FG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [RNA-seq]
PRJNA1235204 | ENA
GenomicsFG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [smallRNA-seq]
Condensates that accumulate small RNA biogenesis factors (nuage) are common in germ cells and often associate with nuclei. In the C. elegans germline, P granules overlay large clusters of nuclear pores and this organization has been proposed to facilitate surveillance of nascent transcripts by Argon...
ORGANISM(S): Caenorhabditis elegans 
2025-03-16 | GSE291761 | GEO
TranscriptomicsFG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [RNA-seq]
Condensates that accumulate small RNA biogenesis factors (nuage) are common in germ cells and often associate with nuclei. In the C. elegans germline, P granules overlay large clusters of nuclear pores and this organization has been proposed to facilitate surveillance of nascent transcripts by Argon...
ORGANISM(S): Caenorhabditis elegans 
2025-03-16 | GSE291760 | GEO
UnknownMolecular interactions of FG nucleoporin repeats at high resolution.
Not available
S-EPMC9630130 | biostudies-literature
UnknownFG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties.
Not available
S-EPMC2728434 | biostudies-literature
UnknownIn-Cell NMR within Budding Yeast Reveals Cytoplasmic Masking of Hydrophobic Residues of FG Repeats.
Not available
S-EPMC6225093 | biostudies-literature
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