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UnknownHijacked in cancer: the KMT2 (MLL) family of methyltransferases.
Not available
S-EPMC4493861 | biostudies-literature
GenomicsClustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers
Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers
PRJNA771366 | ENA
UnknownDiverse functions of PHD fingers of the MLL/KMT2 subfamily.
Not available
S-EPMC3925188 | biostudies-literature
ProteomicsThe phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
Recurrent cancer-causing fusions of NUP98 produce higher-order assemblies known as condensates. How NUP98 oncofusion-driven condensates activate oncogenes remains poorly understood. Here, we investigate NUP98-PHF23, a leukemogenic chimera of the disordered FG-repeats-rich region of NUP98 and the H3K...
ORGANISM(S): Homo sapiens (Human) 
2024-12-31 | PXD056948 | Pride
H3k4me3 Leukemia Histone modification P300 Kmt2/mll Nup98 Wdr5 Fg repeats Condensate Chromatin 
TranscriptomicsFOXQ1 is a critical regulator of the mammary epithelial to mesenchymal transcription program
Purpose: The goals of this study were to uncover the epithelial to mesenchymal transcription program under direct regulation by FOXQ1 and to characterize the KMT2/MLL histone methyl transferase complex as a transcriptional co-activator for the FOXQ1 EMT program.
ORGANISM(S): Homo sapiens 
2020-12-01 | GSE141293 | GEO
UnknownFOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis.
Not available
S-EPMC9626503 | biostudies-literature
UnknownClustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.
Not available
S-EPMC9813062 | biostudies-literature
UnknownMLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres.
Not available
S-EPMC10335677 | biostudies-literature
UnknownSmall-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Not available
S-EPMC3517986 | biostudies-literature
UnknownWDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage.
Not available
S-EPMC6011590 | biostudies-literature
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