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ProteomicsTop-down detection of oxidative protein footprinting by Collision-Induced Dissociation, Electron-Transfer Dissociation and Electron-Capture Dissociation
Fast photochemical oxidation of proteins (FPOP) footprinting is a structural mass spectrometry method that maps proteins by fast and irreversible chemical reactions. The position of oxidative modification reflects solvent accessibility and site reactivity and thus provides information about protein ...
ORGANISM(S): Bos taurus (Bovine) Equus caballus (Horse) 
2023-07-20 | PXD031926 | Pride
Electron-transfer dissociation Fast photochemical oxidation of proteins Top-down Collision-induced dissociation Mass spectrometry. Electron-capture dissociation 
ProteomicsAntibody Characterisation using FFAP
Modern therapeutic approaches, especially for cancer and certain autoimmune disorders, evolved and have started to frequently rely on monoclonal antibodies (mAb) or other recombinantly prepared biomolecules (biopharmaceuticals) instead of on small molecules. The mAb treatment is effective but comes ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044326 | Pride
Covalent labeling Protein structure Mass spectrometry Ffap Togni agents 
ProteomicsFast Fluoroalkylation of Proteins Uncovers Structure and Dynamics of Biological Macromolecules
Stable covalent labeling of proteins in combination with mass spectrometry has been established as a complementary technique to classical structural methods, such as X Ray, NMR, or Cryo-EM used for protein structure determination. Although the current stable covalent labeling techniques enable to mo...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD027310 | Pride
Radical labeling Mass spectrometry Protein footprinting Conformational changes Fluoroalkylation Hyperva-lent iodine reagents Protein structure Togni reagents Protein fingerprinting Epitope mapping Protein surface mapping Radicals Proteomics Interactomics Trifluoromethylation 
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