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ProteomicsFiber type-specific proteomic alterations in R349P desminopathy mice
Desminopathies refer to a group of rare human myopathies and cardiomyopathies, caused by mutations in the desmin gene. So far, there is no causative treatment and little is known about early pathological effects, since alterations in muscle biopsies usually reflect late stages of the disease. Thus, ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD049207 | Pride
Myofibrillar myopathy Desmin Proteomics Fiber types 
ProteomicsHigh-throughput Proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers
Skeletal muscles are composed of a heterogeneous collection of fiber types with different physiological adaption in response to a stimulus and disease-related conditions. Each fiber has a specific molecular expression of myosin heavy chain molecules (MyHC). So far MyHCs are currently the best marker...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD017755 | Pride
Muscle fiber proteomics Protein turnover Phosphoproteomics Myhc profiling 
TranscriptomicsHoxd genes and fiber type-specific markers specify adult mouse muscle type in a diet-independent way
Introduction: The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle group has a specific composition and distribution of the four fiber types. Until now, three genes (CnA, PGC1α and PPARδ) are ident...
ORGANISM(S): Mus musculus 
2010-09-03 | E-GEOD-18127 | biostudies-arrayexpress
ProteomicsSingle muscle fiber proteomics reveals fiber type-specific features of human muscle aging
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers is characterized by diverging metabolic and p...
ORGANISM(S): Homo sapiens (Human) 
2017-06-14 | PXD006182 | Pride
Muscle fibers Skeletal muscle Aging 
ProteomicsAdvanced fiber type-specific protein profiles derived from adult murine skeletal muscle
Skeletal muscle is a heterogeneous tissue consisting of blood vessels, connective tissue, and muscle fibers. The last are highly adaptive and can change their molecular composition depending on external and internal factors, such as exercise, age, and disease. Thus, examination of the skeletal muscl...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-07 | PXD025359 | Pride
Laser microdissection Proteomics Neuromuscular disorders Skeletal muscle Fiber types 
ProteomicsBeyond Myosin Heavy Chains in Human Skeletal Muscle Heterogeneity
Skeletal muscle is an inherently heterogenous tissue comprised primarily of myofibers, which are historically classified into three distinct fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X), delineated by the expression of myosin heavy chain isoforms (MYHs). However, w...
ORGANISM(S): Homo sapiens (Human) 
2025-02-27 | PXD046863 | Pride
Single muscle fiber  cell heterogeneity  myopathy  fiber type 
ProteomicsIdentification of the Key Protein Associated with Different Hair Types in Sheep and Goat
Animal-derived fiber has the characteristics of being light, soft, strong, elastic and a good thermal insulator and it is widely used in many industries and traditional products, so it plays an important role in the economy of some countries. Variations among phenotypes of wool fibers, among species...
ORGANISM(S): Ovis Aries Capra Hircus 
PXD036685 |
ProteomicsSingle muscle fiber proteomics reveals unexpected mitochondrial specialization
Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers according to their contractile and metabolic properties. Here we developed a high sensitivity workflow to characterize the proteome of single fibers. Analysis of segments of the same fiber by traditional and u...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-05 | PXD001641 | Pride
Metabolism Muscle fibers Single cell Exercise Mitochondria 
TranscriptomicsTwo upland cotton tree fiber samples from different seasons
Two fiber tissues harvested 10 days post anthesis from upland cotton trees grown under the same green house conditions except for different seasons of the year were used for RNA extraction. Small RNA molecules under 30 bases were amplified and isolated from an agarose gel. The purified DNA was used ...
ORGANISM(S): Gossypium hirsutum 
2011-07-01 | E-GEOD-27697 | biostudies-arrayexpress
ProteomicsProteomics of slow and fast human muscle fibers reveals extensive fiber type-specific adaptations in response to exercise training
Skeletal muscle plays an important role in the health-promoting effects of exercise training, yet the underlying mechanisms are not fully elucidated. Proteomics of skeletal muscle is challenging due to presence of non-muscle tissues and existence of different fiber types confounding the results. Thi...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD012824 | Pride
Transcription Mitochondrial biogenesis Mhc Glycogen Glucose metabolism Proteome Fiber type 
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