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ProteomicsFilamin C domain 18-21 in vitro kinase assay
In vitro kinase assay with human filamin C domain 18-21 recombinantly expressed in E.coli, purified by Ni2+-NTA beads and incubated with PKC alpha, Akt or a combination of both to identify kinase specific phosphorylation sites.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2020-05-25 | PXD008893 | Pride
Filamin c Akt In vitro kinase assay Pkb Pkcalpha 
ProteomicsProteome alterations in Filamin A deficient granulosa cell tumor-derived KGN cells.
The goal of the study was to evaluate consequences of Filamin A deficiency in granulosa cell tumor-derived KGN cells. Therefore, proteomes of WT and Filamin A deficient KGN cells were quantitatively compared using LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD064136 | Pride
Filamin a Kgn-cells Ovarian cancer Granulosa cells 
ProteomicsHomozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation
Filamin C is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. Recent studies have revealed numerous mutations in the FLNC gene causing familiar and sporadic myopathies and cardiomyopathies with marked clinical variability. The mo...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-09 | PXD020097 | Pride
Lasermicrodissection Myofibrillar myopathies Filaminc Neuromuscular disorders Proteomics 
ProteomicsFILIP1 CT pull-down
FILIP1 was identified as potential new filamin C interaction partner by a SILAC-based BioID experiment. Interaction of the two protein via the carboxy-terminal end of FILIP and domain 18-21 of filamin C was prooven by yeast-2-hybrid sreens and dot-blot assays, respectively. To verify this interactio...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-06 | PXD008875 | Pride
C2c12 myotubes Filip1 Filamin c 
GenomicsFilamin C is Essential for Mammalian Myocardial Integrity
Filamin C is Essential for Mammalian Myocardial Integrity
PRJNA922494 | ENA
UnknownFilamin C is Essential for mammalian myocardial integrity.
Not available
S-EPMC9907827 | biostudies-literature
TranscriptomicsThe Refilin/Filamin complex regulates filipodia dynamics in oligodendrocyte progenitor cells.
Actin assembly and dynamics control the shape, motility and functions of diverse cell types. Programme for controlling theses dynamics is hard-coded into actin binding proteins and regulatory proteins. Refilins (RefilinA and RefilinB) are short lived regulatory proteins that interact with the actin-...
ORGANISM(S): Rattus norvegicus 
2013-05-01 | E-GEOD-37600 | biostudies-arrayexpress
UnknownMutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy.
Not available
S-EPMC3113346 | biostudies-literature
UnknownReduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.
Not available
S-EPMC11179814 | biostudies-literature
UnknownForce-Dependent Structural Changes of Filamin C Rod Domains Regulated by Filamin C Dimer.
Not available
S-EPMC10348313 | biostudies-literature
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