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ProteomicsTumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified tumor-associated macrophages (TAM) in the ascites as promoters of metastasis-associated processes l...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD016555 | Pride
Cancer Tumor-associated macrophages Ascites High-grade serous ovarian carcinoma Tumor microenvironment 
ProteomicsOvarian high grade serous carcinoma ascites cell secretome
The secretomes of tumor cells, and macrophages from high grade serous ovarian carcinoma from the ascites of patients undergoing primary surgery were analysed after 24h culture (ex vivo) via obitrap.
ORGANISM(S): Homo sapiens (Human) 
2017-11-17 | PXD008047 | Pride
Macrophages Cancer Hgsoc Ovca Secretome 
ProteomicsOvarian high grade serous carcinoma ascites cell proteoms
Tumor cells, macrophages and T cells from high grade serous ovarian carcinoma from the ascites of patients undergoing primary surgery were analysed without culturing (ex vivo) via obitrap.
ORGANISM(S): Homo sapiens (Human) 
2017-11-17 | PXD006138 | Pride
Ovca Cancer High grade serous ovarian carcinoma Human Macrophages Hgsoc T cells Ovarian carcinoma 
ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
GenomicsSP1/2/3 and NfY cooccurency in MEFs
Investigation of the binding behaviour of Sp1, Sp2, Sp3 and NF-ya, NF-yb and NF-yc in mouse embryonic fibroblasts and of Sp1, Sp2 and Sp3 in HEK-293 cells reveals distinct binding of the seemingly similar transcription factors Sp1/3 and Sp2.
ORGANISM(S): Mus musculus 
2015-01-30 | E-MTAB-2970 | biostudies-arrayexpress
TranscriptomicsNatural Killer cells treated with arachidonic acid, IL-2 and ascites
Natural killer cells were exptracted from PMBCs of healthy donors, exposed to arachidonic acid, Il-2, both, or ascites and their expression changes identified via RNAseq (QuantSeq).
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-13971 | biostudies-arrayexpress
GenomicsGenome-wide analyses define different classes of PPARbetadelta target genes characterized by distinct modes of transcriptional regulation (Sequencing)
Genome-wide occupancy of PPARbeta/delta in human myofibroblast (WPMY-1 celline) was studied with ChIP-Seq. Additionally, H3K4 trimethylation and RNA polymerase II status was examined.
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-371 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of human WPMY-1 cells with PPARbeta/delta knock down and exposure to PPAR agaonists
Human WPMY-1 cells were depleted for PPARbeta/delta and exposed to the PPAR agonists GW501516.
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MEXP-2756 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analysis of Sp2 Occupancy and Expression Profiling Establish Sp2 as a Sequence-specific Transcription Factor Regulating Fundamental Cellular Processes - Expression Profiling
Mouse embyronic fibroblasts (MEFs) were depleted for transcription factor Specificity Factor 2 (Sp2) via Cre-Recombinase, harvested either 7 days or several weeks post infection and their expression profile compared to mock-infected MEFs.
ORGANISM(S): Mus musculus 
2012-05-24 | E-MTAB-1015 | biostudies-arrayexpress
UnknownHow to resolve cryptic species of polypores: an example in Fomes.
Not available
S-EPMC7325651 | biostudies-literature
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