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ProteomicsProteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls
Tubular atrophy and interstitial fibrosis present the final stage in most forms of progressive kidney diseases. Little is known regarding the early changes in the tubular proteome. In this study, we investigated changes in the tubular proteome of normal or near-normal tubular tissue in the non-clipp...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-12-23 | PXD002106 | Pride
Tubules Ffpe Rat Kidney 
ProteomicsGlomerular proteomic profiling of kidney biopsies with hypertensive nephropathy reveals a signature of disease progression
Background and Objective: Hypertensive nephropathy (HN) requires a kidney biopsy as gold-standard for its diagnosis but histological findings are not entirely specific and lack specific prognostic markers. We aimed at defining prognostic candidate markers based on glomerular protein signatures. Meth...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD026709 | Pride
Human Microdissection Hypertensive nephropathy Kidney Glomerulus Proteomics 
ProteomicsCross-omics analysis of archival human renal cell carcinoma biopsies to identify emerging treatment avenues
Renal cell cancer is among the most common forms of cancer in humans, with around 35,000 deaths attributed to kidney carcinoma in the European Union (EU) in 2012 alone. Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and the most lethal of all genitourinary c...
ORGANISM(S): Homo sapiens (Human) 
2019-04-25 | PXD011681 | Pride
Immunoproteasome Proteomics Kidney cancer Cd74 Cross-omics 
ProteomicsIsolation of spleen lymph during leukemia development
Here we asked whether infiltration of leukemic blasts initiated a response that could be detected in the interstitial fluid phase of the spleen in a rat model known to mimic human acute myeloid leukemia (AML). By cannulating efferent lymphatic vessels, we were able to monitor the response of the spl...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-06-23 | PXD011399 | Pride
Rat Spleen Lymph Lc-ms/ms 
ProteomicsDistinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney, one-clip ratmodel
Background: Hypertensive nephrosclerosis is one of the most frequent causes of chronic kidney failure. Proteome analysis potentially improves the pathophysiological understanding and diagnostic precision of this disorder. In the present exploratory study, we investigated experimental nephrosclerosis...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-02-28 | PXD012889 | Pride
Hypertension 2k1c Juxtamedullary cortex Kidney 
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