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ProteomicsCharacterisation of a cell-free myxoid liposarcoma patient-derived xenograft scaffold model
Myxoid liposarcoma (MLS) is the second most common type of liposarcoma, and today few model systems to study the disease exists. To be able to model the disease in vitro, cell-free scaffolds from MLS patient-derived xenograft (PDX) models were generated. The MLS scaffolds were then used as a 3D grow...
ORGANISM(S): Homo sapiens (Human) 
2024-05-08 | PXD023792 | Pride
Cancer Human Fus-ddit3 expression and tumor microenvironment 
ProteomicsMechano-regulated RNA binding protein hnRNPC contributes to RNA homeostasis in heart failure
Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failure. Cardiomyocytes respond to the ensuing biomechanical stress by re-expressing fetal contractile proteins via transcriptional and post-transcriptional processes, like al...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD020663 | Pride
Proteomics Tmt Ip Hnrnpc Heart failure Rna homeostasis 
TranscriptomicsAffymetrix SNP 6.0 array data for chordoma samples
Chordomas are rare, low to intermediate grade malignant bone tumors of the axial skeleton, believed to originate from the notochord. Treatment options are limited and mainly restricted to surgical excision, as chordomas have been proven to be largely resistant to conventional ionizing radiation and ...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-25720 | biostudies-arrayexpress
ProteomicsATR inhibition enables complete tumour regression in ALK-driven NB mouse models
High-risk neuroblastoma (NB) often involves amplification of the neural MYC (MYCN) oncogene as well as mutations in ALK. Currently, high-risk NB presents significant clinical challenges, and additional therapeutic options are needed. Oncogenes such as MYCN and ALK result in increased replication str...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027187 | Pride
Neuroblastoma Atr inhibitor Phosphorylation Alk 
ProteomicsTitle- Modulation of implanted aortic scaffold- involvement of ECM and immune proteins
Development of a suitable biological scaffold is an essential pre-requisite for functional development of organ including blood vessel. Biological scaffold prepared by conventional means using physical or chemical agent have been shown to cause damage to the extracellular matrix architecture as well...
ORGANISM(S): Rattus rattus (Black rat) Rattus norvegicus (Rat) 
2026-07-06 | PXD021179 | Pride
Acellular Proteomics Immune Tmt Implant Macrophages Vascular scaffold Syn/allogeneic Extracellular matrix 
TranscriptomicsAffymetrix SNP 6.0 array data from neuroendocrine primary tumor and its metastasis
Reports on common mutations in neuroendocrine tumors (NET) are rare and clonality of NET metastases has not been investigated in this tumor entity yet. We selected a NET and a the corresponding lymph node and liver metastases as well as the derivative cell lines to screen for somatic mutations in...
ORGANISM(S): Homo sapiens 
2012-07-16 | E-GEOD-39371 | biostudies-arrayexpress
ProteomicsProteomics identifies lipocalin 2 in neonatal inflammation associated with cerebrovascular alteration in mice and preterm infants
Staphylococcus (S.) epidermidis is one of the most common nosocomial coagulase-negative staphylococci infections in preterm infants. The clinical signs of infection are often unspecific and identification of novel markers to complement the current diagnosis is needed. In this study, we investigated ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD041926 | Pride
N/a 
ProteomicsProteomic changes in adipose tissue and skeletal muscle in women with PCOS
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. The main features of PCOS are hyperandrogenism and irregular menstrual cycles together with metabolic dysfunctions including abdominal obesity, dyslipidemia and an increased risk of developin...
ORGANISM(S): Homo sapiens (Human) 
2024-01-09 | PXD025358 | Pride
Protein expression Human Fat Phosphopeptide Polycystic ovary syndrome 
ProteomicsSubtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies
Cardiac amyloidosis is a severe clinical condition leading to restrictive cardiomyopathy and heart failure. With increasing options for specific treatment of different cardiac amyloid diseases, correct amyloid subtyping is essential for clinical outcome. Mass spectrometry-based methods for cardiac a...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD033168 | Pride
Subtyping Proteomics Endomyocardial biopsies Mass spectrometry Cardiac amyloidosis 
ProteomicsEngineered synthetic eukaryotic vesicles as anti-inflammatory drug delivery system to target Myd88
Mesenchymal stem cells (MSC) secrete naturally extracellular vesicles (EV) with a regenerative profile, and an increasing number of studies have focused on the employment of EV for therapeutic drug delivery. However, EV are usually produced by the cells at low quantities and packed with unnecessary ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033512 | Pride
Mesenchymal stem cells Extracellular vesicles Therapeutic drug delivery Quantitative proteomics Human 
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