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MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
UnknownUse of Plasma-Synthesized Nano-Catalysts for CO Hydrogenation in Low-Temperature Fischer⁻Tropsch Synthesis: Effect of Catalyst Pre-Treatment.
Not available
S-EPMC6215254 | biostudies-literature
ProteomicsChemo-proteomics exploration of HDAC degradability by small molecule degraders
Cells were treated with DMSO (biological triplicate) or degrader at indicated dose and time (Meta Treatment Table) and cells were harvested by centrifugation. Lysis buffer (8 M Urea, 50 mM NaCl, 50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (EPPS) pH 8.5, Protease and Phosphatase inhibito...
ORGANISM(S): Homo sapiens (Human) 
2021-07-30 | PXD023636 | Pride
Protac Imid Degrader Ubiquitin Targeted degradation E3 ligase Hdac 
TranscriptomicsTranscription profiling of rat colon tumors induced by DMH
344 rats were treated twice, one week apart, with subcutaneous injections of 1,2-dimethylhydrazine (150 mg/kg x 2). Thirty-two weeks after the first DMH injection, rats were sacrificed and colonic tumours (T) and normal colon mucosa (NM) harvested and stored in RNAlater. Genomic DNA was extracted f...
ORGANISM(S): Rattus norvegicus 
2010-07-20 | E-MEXP-2487 | biostudies-arrayexpress
ProteomicsDevelopment and Characterization of a Wee1 Kinase Degrader
The G1/S cell-cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells particularly reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Inhibiting regulators of the G2/M checkpoint can therefore drive cancer cells into premature mitosis, ultimately causing cel...
ORGANISM(S): Homo sapiens (Human) 
2019-11-18 | PXD015513 | Pride
Cancer Wee1 Crl4 Crbn Protac Ubiquitin 
UnknownThe role of manganese in CoMnO<sub>x</sub> catalysts for selective long-chain hydrocarbon production via Fischer-Tropsch synthesis.
Not available
S-EPMC11603050 | biostudies-literature
TranscriptomicsToxicogenomic Assessment of Liver Responses following subchronic exposure to furan in Fischer F344 rats [cRNA]
Furan is a widely used industrial chemical and a common contaminant in heated foods. Chronic furan exposure has been shown to cause cholangiocarcinoma and hepatocellular tumors at doses of 2 mg/kg bw/day with gender differences in frequency and severity. The hepatic transcriptional alterations induc...
ORGANISM(S): Rattus norvegicus 
2014-10-30 | E-GEOD-62806 | biostudies-arrayexpress
ProteomicsAcute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation
Over the past few decades, interest in the role that extracellular signal-regulated kinase 5 (ERK5) plays in various diseases, particularly cancer and inflammation, has grown. Phenotypes observed from genetic knockdown or deletion of ERK5 suggested that targeting ERK5 could have therapeutic potentia...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD036104 | Pride
Targeted protein degradation Erk5 Degrader 
ProteomicsAcute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation
Over the past few decades, interest in the role that extracellular signal-regulated kinase 5 (ERK5) plays in various diseases, particularly cancer and inflammation, has grown. Phenotypes observed from genetic knockdown or deletion of ERK5 suggested that targeting ERK5 could have therapeutic potentia...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD036105 | Pride
Targeted protein degradation Erk5 Degrader 
UnknownPore Size Independent Particle Size Control of Mesoporous N-doped Carbon Nanospheres for 3D Bottom-Up Electrode Design.
Not available
S-EPMC12757992 | biostudies-literature
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