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GenomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding...
EGAS00001005060 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
ProteomicsTRX1-enhanced CAR T cells retain their antitumor functions under pro-oxidative conditions
Immunotherapies with CAR-T cells achieve remarkable success, especially against B-cell malignancies. However, their activity against non-hematopoietic solid tumors is very limited. One central cause of this failure may be that a pro-oxidative tumor microenvironment can downmodulate the activation an...
ORGANISM(S): Homo sapiens (Human) 
2022-11-23 | PXD031073 | Pride
Car t cells Ros Immunosuppression Thioredoxin 1 Cancer immunotherapy Redox regulation 
GenomicsRegulating Interleukin-2 activity with engineered receptor signaling clamps
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. Previously, we engineered an IL-2 “superkine” (H9) with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
UnknownExtent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses.
Not available
S-EPMC6362847 | biostudies-literature
Genomics5c638551-978c-4e80-b87e-d669d6b7069e - samples
Full information about the T cell receptor (CR) variable regions found in the sequences of the vdj region. Columns: barcode is_cell contig_id high_confidence length chain v_gene d_gene j_gene c_gene full_length productive cdr3 cdr3_nt reads umis raw_clonotype_id raw_consensus_id
EGAD00001008109 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
TranscriptomicsOne-color microarray of rat bone marrow in response to developmental bisphenol A exposure compared to unexposed controls
Bisphenol A (BPA) is an endocrine disruptor and exposure to low doses in utero has been associated with the development of metabolic diseases. Pregnant rats, Fischer 344/DuCrl, were exposed to BPA via their drinking water from gestational day 3.5 till weaning on post natal day 22.Three dosing grou...
ORGANISM(S): Rattus rattus 
2025-09-05 | E-MTAB-15555 | biostudies-arrayexpress
ProteomicsMass-spectrometry based quantification of HYPK, NAA10 and NAA15 protein steady-state levels in Arabidopsis thaliana mutants carrying a T-DNA insertion in the HYPK gene.
N-alpha terminal acetylation is one of the major protein modifications in eukaryotes carried out by distinct Nats (N-alpha acetyltransferases). The core NatA complex is composed of the catalytic NAA10 and the auxiliary NAA15 subunit and co-translationally acetylates majority of the cytosolic protein...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-12 | PXD023599 | Pride
Arabidopsis thaliana Hypk Nata complex N-alpha terminal acetylation 
Genomics5a9f4bd6-d795-47e9-9690-979bf5b1df6b - samples
The data contains single-cell gene sequencing data (10x Genomics) from FACS-purified CD8 T lymphocytes from two Austrian patients. The cells were stimulated with one MHC class I peptides obtained from a common (wild type) variant and an emerging mutant variant of the SARS-Cov-2 virus. Then the samp...
EGAD00001006995 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
UnknownElevated HbA(1c) levels and the accumulation of differentiated T cells in CMV(+) individuals.
Not available
S-EPMC4589544 | biostudies-literature
UnknownA complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation.
Not available
S-EPMC5566957 | biostudies-literature
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