Sort   by:  
 Page size 
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
TranscriptomicsMicroarray analysis of Merkel cell carcinoma (MCC) tumors, small cell lung cancer (SCLC) tumors, and MCC cell lines
When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. Yet, little has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors. To determine their similarity to MCC tumor samples, we characterized MCC cell lines via g...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-50451 | biostudies-arrayexpress
ProteomicsTargeting Fibrillarin-mediated ribosomal RNA maturation as a novel therapeutic vulnerability in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is among the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options. Ribosome biogenesis has recently emerged as a promising therapeutic target across various cancers. Current ribosome biogenesis inhibitors primarily tar...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD060027 | Pride
Label-free quantitative proteomics Targeting ribosome biogenesis Nanolc-ms/ms Triple-negative breast cancer 
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - Organoid
Individual TFs were overexpressed in fetal lung tip organoids from a doxycycline-inducible construct for 3 days, and organoids were maintained in the self-renewing (tip cell-promoting) medium throughout to rigorously assay the lineage-determining competence of the TF, followed by scRNA-seq. ASCL1, ...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11267 | biostudies-arrayexpress
ProteomicsParkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite
Early-onset Parkinson's disease can be caused by mutations in the gene PARK7. Many functions have been proposed for PARK7, but in vivo evidence is largely lacking or conflicting with enzymological data. Here, we provide unequivocal evidence that PARK7 and its orthologues can prevent damage of protei...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Oryctolagus cuniculus (Rabbit) Saccharomyces cerevisiae (Baker's yeast) Drosophila melanogaster (Fruit fly) 
2022-01-26 | PXD029410 | Pride
Dj1 Phosphoglycerate Phosphoglyceroyl Glycolysis Parkinson's disease Glycerate Glyceroyl Park7 Posttranslational modification 
UnknownA Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions.
Not available
S-EPMC7670262 | biostudies-literature
UnknownNRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Not available
S-EPMC9998367 | biostudies-literature
UnknownA genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.
Not available
S-EPMC11486371 | biostudies-literature
MetabolomicsGNPS - HILIC LC-MS/MS of sputum from CF patients treated with tobramycin
LC-MS/MS HILIC Analysis. The methanol metabolite extracts from three patients for the oxygen experiments with Aspergillus reads (CF157, CF146 and CF353) and three without (CF178, CF243, CF69) were additionally used for the HILIC chromatography analysis to more efficiently detect tobramycin and its m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-17 | MSV000081456 | GNPS
MetabolomicsEcological adaptation and succession of human fecal microbial communities in an automated in vitro fermentation system
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling of gut microbial communities is a major challenge, which can be addressed using in vitro fermenters hosting complex microbial comm...
2021-07-15 | MTBLS2531 | MetaboLights
Sort   by:  
 Page size