Sort   by:  
 Page size 
ProteomicsKi-67 organises heterochromatin during cell proliferation
Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation. Altering Ki-67 expression levels did not significantly affect cell proliferation...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003551 | Pride
Ki-67 interactome Cell proliferation Heterochromatin Mki67 Antigen ki-67 
Unknown3D printed HUVECs/MSCs cocultures impact cellular interactions and angiogenesis depending on cell-cell distance.
Not available
S-EPMC6745276 | biostudies-literature
ProteomicsDynamic regulatory control of plant heteromeric ACCase revealed by spatiotemporal stoichiometry
Despite being comprised of four catalytic subunits and affected by three classes of regulatory proteins, the plastid heteromeric acetyl-CoA carboxylase (hetACCase) remains poorly understood from both structural and protein stoichiometry perspectives. Here, we expanded an AQUA–multiple reaction monit...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-10-31 | PXD078626 | Pride
Fatty acid synthesis Targeted proteomics  aqua–mrm  subunit stoichiometry  metabolic regulation Heteromeric acetyl-coa carboxylase (hetaccase) 
ProteomicsComparative proteomics of reduced protein phosphatase inhibitor-2 expression in the loss of function mutant Arabidopsis
Protein phosphatase inhibitor-2 (PPI-2) is a conserved eukaryotic effector protein that inhibits type one protein phosphatases (TOPP). A transfer-DNA knockdown of AtPPI-2 resulted in stunted growth in both vegetative and reproductive phases of Arabidopsis development. At the cellular level, AtPPI-2 ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-12-14 | PXD006568 | Pride
Arabidopsis Comparative proteomics Type-1 phosphatase Protein-protein interaction Ppi-2 Ribosome biogenesis Phosphatase inhibitor 
ProteomicsUnveiling orphan receptor-like kinases in plants: novel client discovery using high-confidence library predictions in the Kinase–Client (KiC) assay
Plants are remarkable in their ability to adapt to changing environments, with receptor-like kinases (RLKs) playing a pivotal role in perceiving and transmitting environmental cues into cellular responses. Despite extensive research on RLKs from the plant kingdom, the function and activity (i.e., th...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-03-25 | PXD047713 | Pride
Phosphopeptides P2k1 In vitro screening Protein kinase Deep learning 
GenomicsSporadic autism exomes reveal a highly interconnected protein network of de novo mutations

It is well established that autism spectrum disorders (ASD) have a strong genetic component; however, for at least 70% of cases, the underlying genetic cause is unknown. Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no ...

phs000482.v1.p1 | EGA
UnknownChaperonin-Based Biolayer Interferometry To Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins.
Not available
S-EPMC5524994 | biostudies-literature
UnknownThe cell proliferation antigen Ki-67 organises heterochromatin.
Not available
S-EPMC4841783 | biostudies-literature
ProteomicsGlycoproteoforms of osteoarthritis-associated lubricin in plasma and synovial fluid
Lubricin or proteoglycan-4 (PRG-4) is a mucinous glycoprotein that lubricates the cartilage and maintains normal tissue function and cell homeostasis. Altered O- glycoproteforms of lubricin have been found in osteoarthritis (OA) synovial fluid (SF), which could ostensibly be used as a biomarker to...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055049 | Pride
Human Oa Lc-ms Synovial fluid Plasma Lubricin 
ProteomicsHuman induced pluripotent stem cells under dynamic heavy water labeling
Fractional synthesis calibration cells for hiPSC AICS-0052-003 hiPSC (mono-allelic C-terminus mEGFP-tagged MYL7 WTC-11; Allen Institute Cell Collection) line was acquired from Coriell Institute and seeded onto Geltrex (Gibco) coated 6 well plates and maintained in mTesR Plus basal media with Supplem...
ORGANISM(S): Homo Sapiens (human) 
2025-07-23 | PXD060287 | JPOST Repository
Sort   by:  
 Page size