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MetabolomicsMicrobial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, ...
2022-07-28 | MTBLS2331 | MetaboLights
UnknownImatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
Not available
S-EPMC4878082 | biostudies-literature
ProteomicsNuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus
Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular processes, including the...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD080823 | Pride
Tbev Ip-ms Ns5 
ProteomicsImmunological landscape of human lymphoid explants during measles virus infection
In humans, lymph nodes are the primary site of measles virus (MeV) replication. To understand the immunological events that occur at this site, we infected human lymphoid tissue explants using a pathogenic strain of MeV that expresses GFP. We found that MeV infected between 5-15% of cells across don...
ORGANISM(S): Homo sapiens (Human) 
2024-09-10 | PXD054861 | Pride
Lymph node Measles virus 
ProteomicsImmunization of mice with virus-like vesicles of Kaposi sarcoma-associated herpesvirus reveals a role of ORF4 in complement-mediated neutralization
The development of a prophylactic vaccine for Kaposi sarcoma-associated Herpesvirus (KSHV) would prevent consequences from infection including disorders such as Kaposi sarcoma and primary effusion lymphoma. Here, we study the immunogenicity of noninfectious virus-like vesicles (VLVs) of KSHV as a po...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2023-02-01 | PXD035478 | Pride
Kshv herpesvirus 
ProteomicsGeneration of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs
Influenza B virus (IBV) strains are one of the components of seasonal influenza vaccines in both trivalent and quadrivalent formulations. The vast majority of these vaccines are produced in embryonated chickens' eggs. While optimized backbones for vaccine production in eggs exist and are in use for ...
ORGANISM(S): Influenza A virus (A/Florida/2e/2006(H3N2)) Influenza B virus (B/Hawaii/10/2001) Influenza C virus (C/Great Lakes/1167/1954) Influenza C virus 
2023-03-10 | PXD036269 | Pride
Backbone Vaccine Influenza b virus High yield 
ProteomicsQuantitative tissue proteomics reveals increased pathogenesis associated with infection with the SARS-CoV-2 Delta variant that is independent of viral infectivity in Syrian golden hamsters
Background: Since its emergence in 2020, circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been dominated by waves of genetically distinct variants with varying pathogenicity. Understanding the molecular mechanisms underlying SARS-CoV-2 pathogenesis, and the host and viral...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2026-01-26 | PXD054808 | Pride
Sars-cov-2 Proteomics Hamster Phosphoproteomics Pathogenesis 
ProteomicsPrenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities
The bactericidal function of neutrophils are dependent on myriad intrinsic and extrinsic stimuli. Using systems immunology approaches we identified microbiome- and infection-induced changes in neutrophils. We focused on investigating the Prenylcysteine oxidase 1 like (Pcyox1l) protein function. Muri...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-14 | PXD031115 | Pride
Neutrophil Prenylation Pcyox1l 
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
TranscriptomicsTranscription profiling of rat arteries from animals with salt induced hypertensive disease results in over expression of matricellular genes in cerebral arteries
The Dahl salt-sensitive (S) rat model develops chronic hypertensive disease when fed a high salt diet that ultimately results in renal and heart failure, as well as prevalent cerebrovascular pathologies. Phenotypic changes in the cerebral vasculature are preceded by changes in gene expression, and ...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5488 | biostudies-arrayexpress
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