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ProteomicsJEV and ZIKV NS5 interactome
Among the flaviviral proteins, NS5 is the largest and most conserved. NS5 contains major enzymatic components of the viral replication complex. Disruption of the common key NS5-host protein-protein interactions critical for viral replication could aid in the development of broad-spectrum anti-flaviv...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD009523 | Pride
Zikv Jev Ns5 
GenomicsChIP-Seq MyT1-HA in NS5
Here we performed a ChIP-seq experiment on a sample of adherent cultures of mouse neural stem cells (NS5 cell line) expressing an inducible HA-tagged version of the proneural factor MyT1 (MyT1-HA, under TetON control) after activation by doxycycline hyclate (DOX). This resulted in the generation of ...
ORGANISM(S): Mus musculus 
2016-09-09 | E-MTAB-4330 | biostudies-arrayexpress
GenomicsChIP-seq NS5 Zeb1
Here we performed a ChIP-seq experiment on a sample of adherent cultures of mouse neural stem cells (NS5 cell line) under normal growth conditions. This resulted in the generation of a genome-wide map of Zeb1 binding to chromatin.
ORGANISM(S): Mus musculus 
2016-07-01 | E-MTAB-3560 | biostudies-arrayexpress
ProteomicsNuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus
Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular processes, including the...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD080823 | Pride
Tbev Ip-ms Ns5 
ProteomicsHDX-MS Studies of Dengue Virus Serotype 2 NS5 (DENV2 NS5) and Stem Loop A (SLA) Interactions
The project employs HDX-MS to study the conformational dynamics of DENV2 NS5 in its apo form and in complex with the viral promoter RNA, Stem Loop A (SLA). The conformational dynamics of the RdRp domain of DENV2 NS5 (NS5-RdRp) in its apo form and in complex with SLA was also studied.
ORGANISM(S): Escherichia coli 
2025-05-07 | PXD058297 | Pride
Dengue Sla Polymerase Hdx-ms Flavivirus Ns5 
GenomicsHistone ChIP NS5 Ascl1-ERT2
Here we performed a ChIP-seq experiment on a sample of adherent cultures of mouse neural stem cells (NS5 cell line) expressing an inducible version of the proneural factor Mash1/Ascl1 (Ascl1-ERT2) under normal growth conditions and after 24 hours of activation by 4-Hydroxytamoxifen. This resulted in...
ORGANISM(S): Mus musculus 
2015-02-16 | E-MTAB-3104 | biostudies-arrayexpress
GenomicsDHS NS5 Cells
Here we performed DNAse-seq experiments on samples of adherent cultures of mouse neural stem cells (NS5 cell line) under normal growth conditions and upon differentiation by expression of an inducible version of the proneural factor Mash1/Ascl1 (Ascl1-ERT2). This resulted in the generation of genome...
ORGANISM(S): Mus musculus 
2014-10-02 | E-MTAB-2270 | biostudies-arrayexpress
GenomicsChIP-seq NS5 RBPJ
Here we performed a ChIP-seq experiment on a sample of adherent cultures of mouse neural stem cells (NS5 cell line) under normal growth conditions. This resulted in the generation of a genome-wide map of RBPJ binding to chromatin.
ORGANISM(S): Mus musculus 
2016-09-09 | E-MTAB-4494 | biostudies-arrayexpress
GenomicsDHS NS5 Cells
DHS NS5 Cells
PRJEB5275 | ENA
GenomicsChIP NS5 Ascl1-ERT2
Here we performed a ChIP-seq experiment on a sample of adherent cultures of mouse neural stem cells (NS5 cell line) under normal growth conditions and upon short term activation (30 minutes) of an inducible version of the proneural factor Mash1/Ascl1 (Ascl1-ERT2). This resulted in the generation of ...
ORGANISM(S): Mus musculus 
2015-02-16 | E-MTAB-2384 | biostudies-arrayexpress
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