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MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
TranscriptomicsRibosome profiling of chondrocytic cell line SW1353 following exposure to IL-1B
Osteoarthritis is a chronic disease characterised by the loss of articular cartilage in synovial joints through a process of extracellular matrix destruction that is strongly associated with inflammatory stimuli. Chondrocytes undergo changes to their protein translation capacity during osteoarthriti...
ORGANISM(S): Homo sapiens 
2019-07-12 | E-MTAB-7466 | biostudies-arrayexpress
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
ProteomicsRibosomal proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3
Ribosomal proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3 and control condition was assessed.
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD046114 | Pride
Ribosomal proteome Tgfb Sw1353 
ProteomicsCellular proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3
Cellular proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3 and control condition was assessed.
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD046111 | Pride
Yfgb Sw1353 Proteome 
ProteomicsSecretome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3
Secretome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3 and control condition was assessed.
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD046109 | Pride
Tgfb Sw1353 Secretome 
ProteomicsArticular cartilage proteome differentiates by zones during osteoarthritis
Articular cartilage is deprived of blood vessels and nerves, and the only cells residing in this tissue are chondrocytes. The molecular properties of the articular cartilage and the architecture of the extracellular matrix demonstrate a complex structure that differentiates on the depth of tissue. O...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029116 | Pride
Osteoarthritis Zonal changes and ageing 
TranscriptomicsMalaria Cell Atlas: Single cell transcriptomics of malaria parasites
Single-cell RNA-sequencing is revolutionising our understanding of seemingly homogeneous cell populations but has not yet been widely applied to single-celled organisms. Transcriptional variation in unicellular malaria parasites from the Plasmodium genus is associated with critical phenotypes includ...
ORGANISM(S): Plasmodium falciparum 3D7 
2017-02-08 | E-ERAD-611 | biostudies-arrayexpress
ProteomicsComparison of Protein Extraction Methods in Tendon Mass Spectrometry Analysis
Tendons play a fundamental role in the musculoskeletal system and locomotion by transferring forces generated from muscles to the skeleton. Tendon injuries can occur due to sports related incidents, as a result of trauma to overuse or during disease or ageing. Using proteomic techniques tendon prote...
ORGANISM(S): Equus caballus (Horse) 
2018-07-05 | PXD004453 | Pride
Tendon Lc-ms/ms 
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