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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsTranscriptome profiling of the rice blast fungus during invasive plant infection and in vitro stresses
Rice blast is the most threatening disease to cultivated rice worldwide. Magnaporthe oryzae, its causal agent is likely to encounter environmental challenges during invasive growth in the host plants that require shifts in gene expression to establish a compatible interaction. Here, we tested the hy...
ORGANISM(S): Magnaporthe oryzae 
2011-01-24 | E-GEOD-21908 | biostudies-arrayexpress
TranscriptomicsSinus Microbiome Plays a Primary Role in Rhinosinusitis
Persistent mucosal inflammation and microbial infection are characteristic of Chronic Rhinosinusitis (CRS). Though mucosal microbiota dysbiosis is a characteristic feature of other chronic inflammatory diseases, the relationship between sinus microbiota composition and CRS is unknown. Here we demons...
ORGANISM(S): human nasopharyngeal metagenome 
2012-07-31 | E-GEOD-37850 | biostudies-arrayexpress
ProteomicsAmphora coffeaeformis adhesive trail proteomics
Throughout all kingdoms of life, a large number of adhesive biomolecules have evolved to allow organisms to adhere to surfaces underwater. Proteins play an important role in the adhesion of numerous marine invertebrates (e.g. mussels, sea stars, sea urchins) whereas much less is known about the biol...
ORGANISM(S): Amphora coffeiformis 
2021-09-08 | PXD013773 | Pride
Adhesive Diatom 
MetabolomicsCascading effects of root microbial symbiosis on the development and metabolome of the insect herbivore Manduca sexta L

Root mutualistic microbes can modulate the production of plant secondary metabolites affecting plant–herbivore interactions. Still, the main mechanisms underlying the impact of root mutualists on herbivore performance remain ambiguous. In particular, little is known about how changes in the plant...

2023-09-12 | MTBLS2700 | MetaboLights
TranscriptomicsAge-related changes in microRNA levels in serum (mRNA)
Age-related changes in microRNA levels in serum 20 nM biotinylated miRIDIAN miR-1248 mimic (Thermo Scientific) or a negative control, biotinylated miRIDIAN C. elegans miR-67 (here named Con-miR) using Lipofectamine 2000. Forty eight hours post transfection, total RNA was isolated using the mirVana...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-51309 | biostudies-arrayexpress
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
ProteomicsProteomic and phosphoproteomic profiling of D816V- and V560G-mutant KIT cells
The CD117 mast/stem cell growth factor receptor tyrosine kinase (KIT) is critical for haematopoiesis, melanogenesis, and stem cell maintenance. KIT is commonly activated by mutation in cancers including acute myeloid leukaemia, melanoma, and gastrointestinal stromal tumours (GISTs). The kinase and t...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-19 | PXD043783 | Pride
Proteomics Phosphoproteomics Kit Aml 
MetabolomicsResource Partitioning of Diatom Metabolites that Support Bacterial Heterotrophy in the Ocean (UPLC-MS assay)

The communities of marine bacteria that assemble around living microphytoplankton are predictably dominated by three taxonomic groups, each of which specializes in different components of the available metabolite pool: Rhodobacterales transport small and polar metabolites, Flavobacteriia use carb...

2020-09-15 | MTBLS1751 | MetaboLights
MetabolomicsRecombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle
The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor BVIX yields (<0.05%), and is not conducive to scalab...
2021-12-16 | MTBLS3555 | MetaboLights
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