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Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
TranscriptomicsEBV Modulates Host Cell microRNA-194 to Promote IL-10 Production and B Lymphoma Cell Survival
The purpose of this study was to investigate the effect of EBV infection on host cell miR and to characterize the miRNome in EBV+ B cell lymphomas from patients with PTLD. A qPCR array was used to measure the expression level of 377 previously identified miRs from RNA isolated from three sources: to...
ORGANISM(S): Homo sapiens 
2014-09-10 | E-GEOD-61283 | biostudies-arrayexpress
MetabolomicsA combined direct infusion/reversed phase chromatography – high resolution mass spectrometry workflow for accurate absolute lipid quantification with 13C- internal standards
We propose a fully automated novel workflow for lipidomics based on flow injection, followed by liquid chromatography-high-resolution mass spectrometry (FI/LC-HRMS). The workflow combined in-depth characterization of the lipidome achieved via reversed-phase LC-HRMS with absolute quantification by us...
2021-07-01 | MTBLS1876 | MetaboLights
ProteomicsProteome of Cas9- and dCas9-expressing Lucilia cuprina larvae reared on vs. off doxycycline
We analyzed the proteomes of transgenic Cas9- and dCas9-expressing larvae of the Australian sheep blowfly, Lucilia cuprina. We measured abundance of red fluorescent protein (dsRed) in our samples in order to test Cas9 and dCas9 activity. Flies from two transgenic strains, DR7#2;Cas9-ryt and DR7#2;dC...
ORGANISM(S): Lucilia cuprina 
2026-04-27 | PXD071864 | Pride
Insect Blowfly Diptera Tet-off 1d-lc Dcas9 Cas9 Orbitrap astral Calliphoridae Dda Lucilia 
ProteomicsDynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
Insulin acts on adipocytes to control whole-body glucose and lipid metabolism by increasing glucose uptake and inhibiting lipolysis. These processes are dependent on changes in protein localisation (e.g GLUT4 translocation to the plasma membrane (PM)). However, our knowledge of spatial proteomic cha...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-06 | PXD061017 | Pride
Mouse Adipocyte 
TranscriptomicsRNA-Seq of mouse lung vaccinated with subcutaneous BCG and two novel tuberculosis mucosal boosting nanovaccines
Mice were left unvaccinated (Naive) or vaccinated with either BCG alone (BCG) or BCG followed by two intranasal boosting of novel nanovaccines Nano-FP1 or Nano-FP2, 12 and 14 weeks later. A group of mice were also administered a 3rd boost of the corresponding nanovaccine 25 weeks after sc. BCG. Mice...
ORGANISM(S): Mus musculus 
2021-01-28 | E-MTAB-9449 | biostudies-arrayexpress
UnknownSeverity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation.
Not available
S-EPMC4309077 | biostudies-literature
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Not available
S-EPMC4159618 | biostudies-literature
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
UnknownInterleukin-2 therapy in patients with HIV infection.
Not available
S-EPMC2869083 | biostudies-literature
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