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Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
ProteomicsStructural determinants of heparin–transforming growth factor-β1 interactions and their effects on signalling
Transforming growth factor-ß1 (TGF-ß1, Uniprot: P01137) is a heparin-binding protein that has been implicated in a number of physiological processes, including the initiation of chondrogenesis by human mesenchymal stem cells (hMSCs). Here, we identify the molecular features in the protein and in h...
ORGANISM(S): Homo sapiens (Human) 
2015-09-01 | PXD002772 | Pride
Transforming growth factor-β1 Heparan sulfate Heparin Proteoglycans 
ProteomicsMorphological plasticity in a sulfur-oxidizing bacterium from the SUP05 clade enhances dark carbon fixation
Sulfur-oxidizing bacteria from the SUP05 clade are abundant in anoxic and oxygenated marine waters that appear to lack reduced sources of sulfur for cell growth. This raises questions about how these chemosynthetic bacteria survive across oxygen and sulfur gradients and how their mode of survival im...
ORGANISM(S): Candidatus Thioglobus autotrophicus 
2019-05-22 | PXD013243 | Pride
Qexactive hf Gammaproteobacteria Sup05 Shotgun proteomics 
ProteomicsHeterotrophic carbon metabolism and energy acquisition in Candidatus Thioglobus singularis strain PS1, a member of the SUP05 clade of marine Gammaproteobacteria
The balance between autotrophy and heterotrophy regulates the size of the ocean’s carbon sink. The contribution of a particular bacterial or archaeal lineage to carbon flux is determined by its metabolism, which may vary within lineages and may depend on environmental conditions. Members of the SUP...
ORGANISM(S): Candidatus Thioglobus singularis PS1 
2019-04-09 | PXD010624 | Pride
Candidatus thioglobus singularis strain ps1 Marine gammaproteobacteria Sup05 Arctic96bd-19 
ProteomicsStress response of a marine ammonia-oxidizing archaeon informs physiological status of environmental populations
High representation by ammonia-oxidizing archaea (AOA) in marine systems is consistent with their high affinity for ammonia, efficient carbon fixation, and copper (Cu)-centric respiratory system. However, little is known about their response to nutrient stress. We therefore used global transcripti...
ORGANISM(S): Nitrosopumilus maritimus SCM1 
2017-10-27 | PXD007728 | Pride
Marine ammonia oxidizing archaea Nitrosopumilus maritimus (strain scm1) 
ProteomicsProchlorococcus extracellular vesicles: molecular composition and adsorption to diverse microbes
Extracellular vesicles are small (50-200 nm diameter) membrane-bound structures released by cells from all domains of life. Vesicles have been implicated in numerous microbial processes, including gene transfer, signaling, pathogenesis, and defense. While vesicles are abundant in the oceans, little ...
ORGANISM(S): Prochlorococcus marinus str. MIT 9312 Prochlorococcus marinus str. MIT 9313 
2021-11-23 | PXD013602 | Pride
Prochlorococcus Mit9312 Shotgun proteomics Marine cyanobacteria Mit9313 Extracellular vesicles 
TranscriptomicsModification of T cell responses by stem cell mobilization requires direct signalling of the T cell by G-CSF and IL-10
The majority of allogeneic stem cell transplants are currently undertaken using G-CSF mobilized peripheral blood stem cells. G-CSF has diverse biological effects on a broad range of cells and IL-10 is a key regulator of many of these effects. Using mixed radiation chimeras in which the haematopoieti...
ORGANISM(S): Mus musculus 
2014-02-03 | E-GEOD-54616 | biostudies-arrayexpress
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