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TranscriptomicsCpG site methylation of HCV-cirrhotic, HCV-HCC, and normal liver tissues
In this study we used a high-throughput method for assaying methylation of CpG sites simultaneously in a single sample for identifying differences in methylation observed in tissues ranging from normal liver to pre-neoplastic (cirrhosis) and neoplastic (HCC) states. Since there are important clinica...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-GEOD-18081 | biostudies-arrayexpress
TranscriptomicsRMA expression data for liver samples from subjects with HCV cirrhosis with and without concomitant HCC
In this study, we used the Affymetrix HG-U133A 2.0 GeneChip for deriving a multigenic classifier capable of predicting HCV+cirrhosis with vs without concomitant HCC. We studied gene expression in cirrhotic tissues with (N=16) and without (N=47) HCC. Keywords: cross-sectional Liver tissue samples we...
ORGANISM(S): Homo sapiens 
2009-09-11 | E-GEOD-17967 | biostudies-arrayexpress
TranscriptomicsRoot transcriptome remodeling of Arabidopsis in response to high levels of magnesium sulfate
Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars. However, hydrated magnesium sulfate mineral levels in the regolith of Mars can reach as high as 10 wt%, and would be expected to be highly...
ORGANISM(S): Arabidopsis thaliana 
2010-09-17 | E-GEOD-20109 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
UnknownEvaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer.
Not available
S-EPMC6540285 | biostudies-literature
UnknownA population study of clinical trial accrual for women and minorities in neuro-oncology following the NIH Revitalization Act.
Not available
S-EPMC9340618 | biostudies-literature
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [scRNA-seq]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2026-07-12 | E-MTAB-17228 | biostudies-arrayexpress
MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
UnknownPGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2.
Not available
S-EPMC9562873 | biostudies-literature
ProteomicsQuantitative Phosphoproteomic Identification of Novel Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells
The kidney distal convoluted tubule (DCT) plays an important role in body sodium regulation and thus control of blood pressure. The main sodium reabsorption pathways in the DCT are the epithelial sodium channel (ENaC) and the thiazide-sensitive NaCl cotransporter (NCC), the functions of which can be...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001729 | Pride
Phosphoproteomics Vasopressin Signaling networks Quantitation Kidney distal convoluted tubule cells 
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